Keywords: ABCG5; ATP-binding cassette, sub-family G (WHITE), member 5; ABCG8; ATP-binding cassette, sub-family G (WHITE), member 8; ACSL4; acyl-coa synthetase long-chain family member 4; AKT1; V-akt murine thymoma viral oncogene homolog 1; AXIN1; axin 1; Control; C
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Keywords: COL; collagen; FoXO; forkhead box O; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HGF; hepatocyte growth factor; HSP; heat shock protein; IL; interleukin; LAM; laminin; MCP; monocyte chemoattractant protein; MuRF1; muscle RING-finger protein-1; NCIT;
Keywords: AD; Alzheimer's disease; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; CDC14A/B; cell division cycle 14A/B; CDK1; cyclin-dependent kinase 1; DDR1; discoidin domain receptor family 1; DLC1; dynein light chain 1; EMT; epithelial-to-
Keywords: GWAS; genome-wide association study; LD; linkage disequilibrium; MAF; minor allele frequency; SNP; single nucleotide polymorphism; T2DM; type 2 diabetes; Diabetes; Genome wide association; Replication; TCF7L2;
Keywords: SNP; INS; INSR; TCF7L2; PPAR-γ;
miR-182 enhances acute kidney injury by promoting apoptosis involving the targeting and regulation of TCF7L2/Wnt/β-catenins pathway
Keywords: miR-182; Acute kidney injury; Ischemia-reperfusion; Hypoxia; TCF7L2; Wnt/β-catenin signaling pathway;
Transcription factor 7-like 2 gene links increased in vivo insulin synthesis to type 2 diabetes
Keywords: DI; disposition index; eGFR; estimated glomerular filtration rate; FSR; fractional synthesis rate; GC-MS; gas chromatography-mass spectrometry; IAC; immunoaffinity chromatography; OGTT; oral glucose tolerance test; OMM; oral minimal model; SI; insulin s
Association of Native American ancestry and common variants in ACE, ADIPOR2, MTNR1B, GCK, TCF7L2 and FTO genes with glycemic traits in Colombian population
Keywords: ACE; angiotensin converting enzyme; MTNR1B; melatonin receptor 1B; GCK; glucokinase; TCF7L2; transcription factor 7 Like 2; FTO; alpha-ketoglutarate dependent dioxygenase; OR; odds ratio; IR; insulin resistance; T2D; type 2 diabetes; MS; metabolic syndrom
Genetic polymorphisms of human transcription factor-7 like 2 (TCF7L2), β-defensin (DEFB1) and CD14 genes in nephrolithiasis patients
Keywords: TCF7L2; CD14; β-Defensin;
Interrelationship of the rs7903146 TCF7L2 gene variant with measures of glucose metabolism and adiposity: The NEO study
Keywords: TCF7L2; Glucose; Insulin; Diabetes; Adiposity;
TCF7L2 mediates the cellular and behavioral response to chronic lithium treatment in animal models
Keywords: Bipolar disorder; Lithium treatment; Wnt signaling; β-catenin; TCF7L2; Behavior;
Tcf7l2 plays crucial roles in forebrain development through regulation of thalamic and habenular neuron identity and connectivity
Keywords: Tcf7l2; Forebrain; Thalamus; Habenula; Axon guidance; Differentiation; Mice;
Association between the TCF7L2 polymorphism and colorectal cancer does not differ by diabetes and obesity statuses
Keywords: Colorectal cancer; Risk factor; TCF7L2; Diabetes; Obesity;
Common variants in TCF7L2 and CDKAL1 genes and risk of type 2 diabetes mellitus in Egyptians
Keywords: Type 2 diabetes mellitus; TCF7L2; CDKAL1; Polymorphism;
HMGB1 binds to the rs7903146 locus in TCF7L2 in human pancreatic islets
Keywords: TCF7L2; Type 2 diabetes; HMGB1; Chromatin binding
Current understanding and dispute on the function of the Wnt signaling pathway effector TCF7L2 in hepatic gluconeogenesis
Keywords: β-Catenin; Gluconeogenesis; Insulin; TCF7L2; Transgenic mice; Type 2 diabetes; Wnt
Genetic variations in TCF7L2 influence therapeutic response to sulfonylureas in Indian diabetics
Keywords: TCF7L2; Variations; Diabetes; Sulfonylureas;
Polymorphisms in FTO and TCF7L2 genes of Euro-Brazilian women with gestational diabetes
Keywords: Gestational diabetes mellitus; FTO; TCF7L2; Polymorphisms; Case-controlled study; SNP;
Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with impaired proinsulin conversion-A meta-analysis
Keywords: TCF7L2; rs7903146; Type 2 diabetes mellitus; Impaired proinsulin conversion; Meta-analysis;
The expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage causes impaired glucose homeostasis
Keywords: GLP-1; GSIS; Pancreatic β-cells; TCF7L2; TCF7L2DN; Wnt; Incretin receptors
Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo
Keywords: c-Myc; cyclin D1; DIF-3; TCF7L2; Wnt/β-catenin signaling pathway
Acute Wnt pathway activation positively regulates leptin gene expression in mature adipocytes
Keywords: GWAS; genome-wide association studies; T2D; type 2 diabetes; SNPs; single nucleotide polymorphisms; TCF7L2; transcription factor 7-like 2; TCF7L2DN; dominant-negative TCF7L2; β-cat; β-catenin; Dact1; dishevelled-binding antagonist of beta-catenin 1; SFR
A gene variant in the transcription factor 7-like 2 (TCF7L2) is associated with an increased risk of gestational diabetes mellitus
Keywords: Single-nucleotide polymorphism; Adiponectin; Resistin; TCF7L2; Gestational diabetes mellitus;
Untangling the interplay of genetic and metabolic influences on beta-cell function: Examples of potential therapeutic implications involving TCF7L2 and FFAR1
Keywords: Beta-cell function; Beta-cell failure; TCF7L2; FFAR1; Gene×environment interaction; Pharmacogenetics; Incretin resistance
5-Fluorouracil causes severe CNS demyelination by disruption of TCF7L2/HDAC1/HDAC2 complex in adolescent mice
Keywords: 5-FU; TCF7L2; Demyelination; Adolescence; Oligodendrocyte;
Malondialdehyde regulates glucose-stimulated insulin secretion in murine islets via TCF7L2-dependent Wnt signaling pathway
Keywords: Malondialdehyde; Hyperinsulinemia; Diabetes; Glucose-stimulated insulin secretion; Wnt signaling pathway; TCF7L2;
DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice
Keywords: DIF-1; TCF7L2; GSK-3β; Wnt/β-catenin signaling pathway; Egr-1
CNBP modulates the transcription of Wnt signaling pathway components
Keywords: CNBP; cellular nucleic acid binding protein; ZNF9; zinc-finger protein 9; CNC; cranial neural crest; CNBP-CBS; CNBP DNA-consensus binding sequence; cdk14; cyclin-dependent kinase 14; tcf7l2; T-cell specific, HMG-box transcription factor 7-like 2; ptk7; pr
Methods PaperAssociation of TCF7L2 gene polymorphisms with type 2 diabetes mellitus in Han Chinese population: A meta-analysis
Keywords: TCF7L2; transcription factor 7-like 2; T2DM; type 2 diabetes mellitus; HWE; Hardy-Weinberg equilibrium; SNPs; single nucleotide polymorphisms; OGTT; oral glucose tolerance test; BMI; body mass index; OR; odds ratio; CIs; confidence intervals; TCF7L2; Ge
Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes
Keywords: TCF7L2; Diabetes; Polymorphism; Gene expression; Splicing; EMSA; Electrophoretic mobility shift assay; FAIRE; Formaldehyde-assisted isolation of regulatory elements; GWAS; Genome-wide association study; MC-EMSA; Multiplexed competitor-electrophoretic mobi
Research ArticleAssociation between donor and recipient TCF7L2 gene polymorphisms and the risk of new-onset diabetes mellitus after liver transplantation in a Han Chinese population
Keywords: NODM; new-onset diabetes mellitus; LT; liver transplantation; TCF7L2; transcription factor 7-like 2; SNP; single nucleotide polymorphism; PCR-RFLP; PCR restriction fragment length polymorphism; AUROC; area under the receiver operating characteristic curve
Nor-1, a novel incretin-responsive regulator of insulin genes and insulin secretion ⋆
Keywords: Nor-1; Insulin gene expression; Insulin secretion; Incretin resistance; TCF7L2
Genetic prediction of postpartum diabetes in women with gestational diabetes mellitus
Keywords: FTO; Gestational diabetes mellitus (GDM); Postpartum diabetes; Risk prediction; Risk score; TCF7L2
Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects
Keywords: GWAS, genome-wide association studies; LD, linkage disequilibrium; MAF, minor allele frequencies; SNP, single nucleotide polymorphism; T2DM, type 2 diabetesDiabetes; Genome wide association; Replication; TCF7L2
Genetic variants of TCF7L2 are associated with type 2 diabetes in a northeastern Chinese population
Keywords: TCF7L2, transcription factor 7-like 2; T2D, type 2 diabetes mellitus; BMI, body mass index; OR, odds ratio; CI, confidence interval; LDR, ligase detection reactionsNortheastern Han Chinese; TCF7L2; rs290487; Type 2 diabetes
Relationship of transcription factor 7 like 2 gene rs7903146 variation with type 2 diabetes and obesity related parameters
Keywords: TCF7L2; rs7903146 polymorphism; Serum lipids; Fat mass; Obesity; Insulin resistance
The expression of transcription factor 7-like 2 (TCF7L2) in fat and placental tissue from women with gestational diabetes
Keywords: TCF7L2; TNF-α; Adipose tissue; Placenta; Gestational diabetes
At-Risk Variant in TCF7L2 for Type II Diabetes Increases Risk of Schizophrenia
Keywords: Diabetes type II; genetic risk variants; rs7903146; schizophrenia; TCF7L2
Transcription factor 7-like 2 (TCF7L2) gene polymorphism and complication/comorbidity profile in type 2 diabetes patients
Keywords: Diabetic nephropathy; Gene polymorphism; Risk alleles; TCF7L2; Type 2 diabetes;
rs12255372 Variant of TCF7L2 Gene Is Protective for Obesity in Mexican Children
Keywords: TCF7L2; Obesity; rs12255372; Children; Gene; SNP
Association of transcription factor 7-like 2 (TCF7L2) gene polymorphism with posttransplant diabetes mellitus in kidney transplant patients medicated with tacrolimus
Keywords: posttransplant diabetes mellitus (PTDM); TCF7L2; genetic polymorphism;
Lithium induces c-Ret expression in mouse inner medullary collecting duct cells
Keywords: Li+; lithium; mIMCD; murine inner medullary collecting duct; GSK-3β; glycogen synthase kinase 3β; BIO; 6-bromoindirubin-3â²-oxime; TCF/LEF; T cell factor/lymphoid enhancer factor; mTOR; mammalian target of rapamycin; Ret; REarranged during Transfection
TCF7L2 is associated with type 2 diabetes in nonobese individuals from Tunisia
Keywords: Obesity; Genetic polymorphism; TCF7L2; Type 2 diabetesObésité; Polymorphisme génétique; TCF7L2; Type 2 diabète
TCF7L2 rs12255372 and SLC30A8 rs13266634 confer susceptibility to type 2 diabetes in a Russian population
Keywords: TCF7L2; SLC30A8; Type 2 diabetes; Insulin secretion; Russian population
Frameshift mutations of Wnt pathway genes AXIN2 and TCF7L2 in gastric carcinomas with high microsatellite instability
Keywords: Microsatellite instability; Mutation; AXIN2; TCF7L2; Gastric cancer; Wnt
Genetic risk factors for type 2 diabetes with pharmacologic intervention in African-American patients with schizophrenia or schizoaffective disorder
Keywords: TCF7L2; CAPN10; ENPP1; Antipsychotics
Meta-analysis of the association between SNPs in TCF7L2 and type 2 diabetes in East Asian population
Keywords: Meta-analysis; Diabetes; Type 2; TCF7L2
Molecular development of the lateral geniculate nucleus in the absence of retinal waves during the time of retinal axon eye-specific segregation
Keywords: PCP4; TCF7L2; visual system; spontaneous activity; mouse; ferret; AC1; adenylate cyclase 1; BCIP; 5-bromo-chloro-3-indolyl-phosphate; CaMKII; calcium/calmodulin-dependent protein kinase II; CTB; cholera toxin B subunit; LGN; lateral geniculate nucleus; Lh