کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10816042 1058539 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
KIBRA: In the brain and beyond
ترجمه فارسی عنوان
کیبرا: در مغز و فراتر از آن
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
In mammals, the KIBRA locus has been associated with memory performance and cognition by genome-wide single nucleotide polymorphism screening. Genetic studies in Drosophila and human cells have identified KIBRA as a novel regulator of the Hippo signaling pathway, which plays a critical role in human tumorigenesis. Recent studies also indicated that KIBRA is involved in other physiological processes including cell polarity, membrane/vesicular trafficking, mitosis and cell migration. At the biochemical level, KIBRA protein is highly phosphorylated by various kinases in epithelial cells. Here, we discuss the updates concerning the function and regulation of KIBRA in the brain and beyond.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 26, Issue 7, July 2014, Pages 1392-1399
نویسندگان
, , , , , ,