Keywords: پروتئین مرتبط با بله; Human pluripotent stem cells; Endothelial cells; Smooth muscle cells; Biomechanical cues; Vascular differentiation; Con-vSMCs; contractile vSMCs; CXCR4; C-X-C chemokine receptor type 4; ECM; Extracellular matrix; ECs; Endothelial cells; hESCs; Human embry
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Keywords: پروتئین مرتبط با بله; BMP; bone morphogenetic protein; CTGF; connective tissue growth factor; ECM; extracellular matrix; EMT; epithelial-mesenchymal transformation; Glut1; glucose transporter 1; GPCR; G protein-coupled receptor; KS; Kaposi's sarcoma; LATS; large tumor suppress
Keywords: پروتئین مرتبط با بله; AANAT; arylalkylamine N-acetyltransferase; AE2; Clâ/HCO3- anion exchanger 2; ANIT; α-naphthylisothiocyanate; BA; biliary atresia; BDL; bile duct ligation; cAMP; adenosine 3â²,5â²-cyclic monophosphate; CCA; cholangiocarcinoma; CCl4; carbon tetrachlo
Keywords: پروتئین مرتبط با بله; CHAPS; 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate; ALI; air-liquid interface; α-SMA; alpha-smooth muscle actin; ATII; alveolar type II cells; ATS; American Thoracic Society; AFM; atomic force microscopy; COPD; Chronic Obstructive Pulmonary
Keywords: پروتئین مرتبط با بله; BMP; Bone Morphogenic Protein; Cdx2; caudal type homeobox 2; C/EBP; CCAAT/Enhancer Binding Protein; ES; embryonic stem; FGF; Fibroblast Growth Factor; FoxA; Forkhead box factor A; GRN; gene regulatory network; Grg3; groucho-related gene 3; HNF; Hepatocyte
Keywords: پروتئین مرتبط با بله; Telomerase; TERT; Cancer stemness; CSCs; Positive feedback loops; Targeted anticancer therapy; ABC; ATP-binding cassette; Akt; protein kinase B; ALDH1; aldehyde dehydrogenase 1; BAX; BCL-2-associated protein X; BCL; B-cell lymphoma family protein; BMI-1;
Keywords: پروتئین مرتبط با بله; Cancer stem-like cells; Mevalonate cascade; Ras; Rho; Stemness; Statins; Yap; ACAT; acetoacetyl-CoA transferase; acetyl-CoA; acetyl-coenzyme A; Arp2/3; actin-related protein 2/3 (actin polymerizing complex); BPs; bisphosphonates; CAMs; cell adhesion molec
Keywords: پروتئین مرتبط با بله; 2D; two-dimensional; 3D; three-dimensional; Cry2; Cryptochrome 2; ECM; extracellular matrix; FAK; focal adhesion kinase; FRET; fluorescence resonance energy transfer; MRTF; myocardin-related transcription factor; SRF; serum response factor; TAZ; transcrip
Keywords: پروتئین مرتبط با بله; BrdU; 5â²-bromo-deoxyUridine; DPP-IV; dipeptidyl-peptidase type IV; GFP; green fluorescent protein; PH; 2/3 partial hepatectomy; PFA; paraformaldehyde; RS; retrorsine; SA-β-gal; senescence-associated-β-gactosidase; YAP; yes-associated protein; Aging; L
Keywords: پروتئین مرتبط با بله; AD; Alzheimer's disease; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; CDC14A/B; cell division cycle 14A/B; CDK1; cyclin-dependent kinase 1; DDR1; discoidin domain receptor family 1; DLC1; dynein light chain 1; EMT; epithelial-to-
BmYki is transcribed into four functional splicing isoforms in the silk glands of the silkworm Bombyx mori
Keywords: پروتئین مرتبط با بله; Yki; Drosophila Yorkie; BmYki; Bombyx mori Yorkie; HaYki; Helicoverpa armigera Yorkie; YAP; Yes-associated protein; TAZ; transcriptional co-activator with PDZ-binding motif; BmE; Bombyx mori embryonic cells; BmN; Bombyx mori ovary-derived cells; BmA4; Bom
Axis of serotonin -pERK-YAP in liver regeneration
Keywords: پروتئین مرتبط با بله; Serotonin; Yes-associated protein; Phospho-extracellular signal-regulated kinases; TPH1â/â mice; Liver regeneration;
Induction of miR-15a expression by tripterygium glycosides caused premature ovarian failure by suppressing the Hippo-YAP/TAZ signaling effector Lats1
Keywords: پروتئین مرتبط با بله; TGs; Tripterygium glycosides; LATS1/2; Large tumor suppressor 1/2; YAP; Yes-associated protein; TAZ; Transcriptional coactivator with PDZ-binding motif; H&E; Hematoxylin-eosin; PI; Propidium iodide; OGCs; ovarian granulosa cells; POF; premature ovarian fa
Cyclin-dependent kinase 1-mediated phosphorylation of YES links mitotic arrest and apoptosis during antitubulin chemotherapy
Keywords: پروتئین مرتبط با بله; YES; Mitotic phosphorylation; CDK1; Taxol sensitivity; Chemotherapy; CDK1; cyclin-dependent kinase 1; CDKN1A (p21); cyclin-dependent kinase inhibitor 1A; CRISPR; clustered regularly-interspaced short palindromic repeats; KO; knockout; Plk1; Polo-like kina
COX-2 Forms Regulatory Loop with YAP to Promote Proliferation and Tumorigenesis of Hepatocellular Carcinoma Cells
Keywords: پروتئین مرتبط با بله; HCC; hepatocellular carcinoma; HB; hepatoblastoma; TEAD; TEA domain; CTGF; connective tissue growth factor; Cyr61; gene encoding cysteine rich 61; COX; cyclooxygenase; YAP; Yes-associated protein; PGE2; prostaglandin E2; VP; verteporfin; Cel; celecoxib; E
Inhibiting RHOA Signaling in Mice Increases Glucose Tolerance and Numbers of Enteroendocrine and Other Secretory Cells in the Intestine
Keywords: پروتئین مرتبط با بله; Mouse Model; Type 2 Diabetes; Enteroendocrine Cells; Signal Transduction; CCK; cholecystokinin; Ctgf; connective tissue growth factor; Cyr61; cysteine-rich angiogenic inducer 61; Dll1; delta-like protein 1; DBZ; dibenzazepine; EdU; 5-ethynyl-2â²-deoxyuri
AJUBA increases the cisplatin resistance through hippo pathway in cervical cancer
Keywords: پروتئین مرتبط با بله; YAP; Yes-associated protein; Lats1/2; large tumor suppressor; ESCC; esophageal squamous cell carcinoma; IHC; immunohistochemistry; EMT; epithelial-to-mesenchymal transition; Cervical cancer; AJUBA; Cisplatin resistance; Hippo signaling pathway;
Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis
Keywords: پروتئین مرتبط با بله; Akt; protein kinase B; CTGF; connective tissue growth factor; DMF; dimethyl fumarate; EDN1; endothelin 1; GSK-3; glycogen kinase 3; HC; healthy control; MMP; matrix metalloproteinase; NRF2; nuclear factor (erythroid-derived 2)-like 2; PAAm; polyacrylamide
Ovatodiolide suppresses yes-associated protein 1-modulated cancer stem cell phenotypes in highly malignant hepatocellular carcinoma and sensitizes cancer cells to chemotherapy in vitro
Keywords: پروتئین مرتبط با بله; Hepatocellular carcinoma; Yes-associated protein; YAP1; Ovatodiolide; Side-population; Cancer stemness; Cancer stem cells (CSCs); Chemoresistance;
Overexpression of Rac GTPase Activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis
Keywords: پروتئین مرتبط با بله; Binucleated Cells; Large Tumor Suppressor Kinase; Pan-overexpressed; TEA Domain Transcription Factor; AURKB; aurora B kinase; ChIP; chromatin immunoprecipitation; CIN; chromosomal instability; CNL; noncancerous tissue; ECT2; epithelial cell transforming 2
Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells
Keywords: پروتئین مرتبط با بله; Liver Diseases; Metabolic Reprogramming; Fibrogenesis; Hippo Pathway; α-KG; alpha-ketoglutarate; α-SMA; alpha-smooth muscle actin; BPTES; bis-2-[5-phenylacetamido-1,2,4-thiadiazol-2-yl] ethyl sulfide; DKG; dimethyl α-ketoglutarate; EGCG; epigallocatech
Emerging paradigms in the treatment of liver metastases in colorectal cancer
Keywords: پروتئین مرتبط با بله; CRC; colorectal cancer; mCRC; metastatic colorectal cancer; CLM; colorectal liver metastases; SR; surgical resection; PVE; portal vein embolism; RFA; radiofrequency ablation; APC; adenomatous polyposis coli; LOH; loss of heterozygosity; EGFR; epidermal gr
Paving the Rho in cancer metastasis: Rho GTPases and beyond
Keywords: پروتئین مرتبط با بله; ADP; adenosine diphosphate; AMP; adenosine monophosphate; AMT; amoeboid-mesenchymal transition; APC; adenomatosis polyposis coli; Arp2/3; actin related protein 2/3; Cdc42; cell division control protein 42 homolog; CK1; casein kinase 1; COX-2; cyclooxygena
Impact of obesity and overweight on DNA stability: Few facts and many hypotheses
Keywords: پروتئین مرتبط با بله; AGEs; advanced glycation end products; AP-1; activating protein -1; APE1; apurinic/apyrimidinic endonuclease 1; BER; base excision repair; BMI; body mass index; CAF; cafeteria diet; CAT; Catalase; CBMN-Cyt; cytokinesis block micronucleus cytome assay; CEL
MiR-361 targets Yes-associated protein (YAP) mRNA to suppress cell proliferation in lung cancer
Keywords: پروتئین مرتبط با بله; miR-361; YAP; Proliferation; Lung cancer; YAP; Yes-associated protein; miRNA; microRNA; STAT6; signal transducer and activator of transcription-6; real time-PCR; real-time polymerase chain reaction; EdU; 5-ethynyl-2â²-deoxyuridine;
Mini-reviewThe Hippo pathway in hepatocellular carcinoma: Non-coding RNAs in action
Keywords: پروتئین مرتبط با بله; Hepatocellular carcinoma; The Hippo pathway; Long non-coding RNA; microRNA; Yes-associated protein;
Original ArticleA combinatorial strategy using YAP and pan-RAF inhibitors for treating KRAS-mutant pancreatic cancer
Keywords: پروتئین مرتبط با بله; Yes-associated protein (YAP); RAF inhibitor; Pancreatic ductal adenocarcinoma (PDAC); Combinational therapy; Verteporfin; PDAC; Pancreatic ductal adenocarcinoma; YAP; Yes-associated protein; MAP; mitogen-activated protein; IHC; immunohistochemical; DMEM;
Original ArticleSUMOylation of large tumor suppressor 1 at Lys751 attenuates its kinase activity and tumor-suppressor functions
Keywords: پروتئین مرتبط با بله; SUMOylation; Lats1; Hippo signaling; Tumor suppressor; SUMO; Small ubiquitin-like modifier; Lats; large tumor suppressor; YAP; Yes-associated protein; TAZ; transcriptional co-activator with PDZ-binding motif; Tead; TEA domain transcription factor; CTGF; c
Synergistic induction of CTGF by cytochalasin D and TGFβ-1 in primary human renal epithelial cells: Role of transcriptional regulators MKL1, YAP/TAZ and Smad2/3
Keywords: پروتئین مرتبط با بله; CTGF; connective tissue growth factor, CCN2; CytoD; cytochalasin D; G-actin; globular actin; F-actin; filamentous actin; hPTEC; human primary tubular epithelial cells; LatB; latrunculin B; MKL1; Megakaryoblastic Leukemia 1; MYPT; myosin phosphatase target
Biomechanical strain-induced modulation of proliferation coincides with an ERK1/2-independent nuclear YAP localization
Keywords: پروتئین مرتبط با بله; ECM; extracellular matrix; ERK; extracellular signal-regulated kinase; FA; focal adhesion; FAK; focal adhesion kinase; hPDLF; human periodontal ligament fibroblast; IIF; indirect immunofluorescence; MAPK; mitogen activated protein kinase; MEK; MAPK/ERK ki
Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis
Keywords: پروتئین مرتبط با بله; YAP1; YES-Associated Protein; WWTR1; TAZ; AJ; adherens junction; AMOT; angiomotin; CC; cholangiocardinoma; HB; hepatoblastoma; HCC; hepatocellular carcinoma; HepSC; hepatic stellate cell; LATS; large tumor suppressor kinase; PI3K; phosphoinositide 3-kinas
Comparative analysis of osteoblast gene expression profiles and Runx2 genomic occupancy of mouse and human osteoblasts in vitro
Keywords: پروتئین مرتبط با بله; NGS; next generation sequencing; ChIP; chromatin immunoprecipitation; ChIP-seq; chromatin immunoprecipitation followed by deep sequencing; TF; transcription factor; MSC; mesenchymal stem cell; DE; differentially expressed; TSS; transcriptional start site;
Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice
Keywords: پروتئین مرتبط با بله; Inflammation; Tumorigenesis; Villus Regeneration; Mouse Model; ANKRD1; ankyrin repeat domain 1; APC; adenomatous polyposis coli; ChIP; chromatin immunoprecipitation; COX-2; cyclooxygenase 2; CREB; cyclic adenosine monophosphate response element binding pr
Redox regulation of the actin cytoskeleton and its role in the vascular system
Keywords: پروتئین مرتبط با بله; α; alpha; β; beta; γ; gamma; G-actin; globular actin; F-actin; filamentous actin; ROS; reactive oxygen species; O2â¢â; superoxide; H2O2; hydrogen peroxide; HOâ¢; hydroxyl radical; RNS; reactive nitrogen species; NO; nitric oxide; â¢NO2; nitrogen d
Direct coupling of the HER4 intracellular domain (4ICD) and STAT5A signaling is required to induce mammary epithelial cell differentiation
Keywords: پروتئین مرتبط با بله; 4ICD; HER4 intracellular domain; ATCC; American type culture collection; EGF; epidermal growth factor; EGFP; enhanced green fluorescent protein; EGFR; epidermal growth factor family; ERα; estrogen receptor alpha; FBS; fetal bovine serum; HEK; human embry
The endothelial E3 ligase HECW2 promotes endothelial cell junctions by increasing AMOTL1 protein stability via K63-linked ubiquitination
Keywords: پروتئین مرتبط با بله; AMOT; angiomotin; AMOTL1; angiomotin-like 1; AMOTL2; angiomotin-like 2; YAP; yes-associated protein; ANG-2; angiopoietin-2; VE-cadherin; vascular endothelial cadherin; EPC; endothelial progenitor cell; OEC; outgrowing endothelial cell; HUVEC; human umbili
Atheroprotective laminar flow inhibits Hippo pathway effector YAP in endothelial cells
Keywords: پروتئین مرتبط با بله; CTGF; connective tissue growth factor; Cyr61; Cysteine-rich protein 61; DF; disturbed flow; EC; endothelial cells; LATS1/2; large tumor suppressor kinase 1/2; LF; laminar flow; YAP; Yes-associated protein;
MST2 phosphorylation at serine 385 in mitosis inhibits its tumor suppressing activity
Keywords: پروتئین مرتبط با بله; CDK1; cyclin-dependent kinase 1; LATS1/2; large tumor suppressor 1/2; MST1/2; mammalian sterile 20-like kinase 1/2; PLK1; polo-like kinase 1; TAZ; transcriptional co-activator with PDZ binding domain; YAP; yes-associated protein; MST2; Mitotic phosphoryla
Research ArticleAccumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease
Keywords: پروتئین مرتبط با بله; YAP; yes-associated protein; RDC; reactive-appearing ductular cells; NAFLD; non-alcoholic fatty liver disease; NASH; non-alcoholic steatohepatitis; Shh; sonic hedgehog; WT; wild-type; MCD; methionine choline deficient; IHC; immunohistochemistry; TUNEL; te
Drosophila Myc: A master regulator of cellular performance
Keywords: پروتئین مرتبط با بله; ACC; acetyl CoA carboxylase; bHLH/LZ; basic helix-loop-helix leucine zipper; Brk; Brinker; CK1α; casein kinase 1α; Desat1; desaturase-1; DILPs; Drosophila insulin like peptides; Dlg; discs large; dm; diminutive; Dpp; decapentaplegic; FAS; fatty acid syn
Hypoxia induced E-cadherin involving regulators of Hippo pathway due to HIF-1α stabilization/nuclear translocation in bone metastasis from breast carcinoma
Keywords: پروتئین مرتبط با بله; EMT; epithelial-mesenchymal transition; MET; mesenchymal-epithelial transition; HIF-1; hypoxia inducible factor-1; TAZ; transcriptional co-activator with PDZ-binding motif; YAP; Yes-associated protein; Wwox; WW-domain containing oxidoreductase; MDM2;
YAP Expression in Normal and Neoplastic Breast Tissue: An Immunohistochemical Study
Keywords: پروتئین مرتبط با بله; Yes-associated protein; Breast cancer; Immunohistochemistry
The PDZ-binding motif of Yes-associated protein is required for its co-activation of TEAD-mediated CTGF transcription and oncogenic cell transforming activity
Keywords: پروتئین مرتبط با بله; YAP; Yes-associated protein; CTGF; connective tissue growth factor; TEAD; TEA domain family member; TAZ; transcriptional co-activator with PDZ-binding motif; YAP; Hippo pathway; CTGF; TEAD;
Wnt signaling in adult intestinal stem cells and cancer
Keywords: پروتئین مرتبط با بله; APC; Adenomatous Polyposis Coli; Axin; axis inhibition protein; β-TrCP; beta-transducin repeat containing protein; BMP; bone morphogenic protein; CBC; crypt base columnar; CRC; colorectal carcinoma; CSCs; cancer stem cells; Dkk; Dickkopf; FAP; Familial A
Molecular basis of the binding of YAP transcriptional regulator to the ErbB4 receptor tyrosine kinase
Keywords: پروتئین مرتبط با بله; WW-ligand thermodynamics; PPXY motifs; Structural analysis; Conformational dynamics; ErbB4; erythroblastic (Erb) leukemia viral oncogene homolog B4; ITC; isothermal titration calorimetry; ITCH; ubiquitin ligase itchy homolog; LIC; ligation-independent clo
Mutual inhibition between YAP and SRSF1 maintains long non-coding RNA, Malat1-induced tumourigenesis in liver cancer
Keywords: پروتئین مرتبط با بله; IF; immunofluorescence; IHC; immunohistochemistry; TMA; tissue microarray analysis; ChIP; chromatin immunoprecipitation; YAP; Yes-associated protein; SRSF1; serine/arginine-rich splicing factor 1; MALAT1; metastasis-associated lung adenocarcinoma transcri
Activation of β-Catenin and Yap1 in Human Hepatoblastoma and Induction of Hepatocarcinogenesis in Mice
Keywords: پروتئین مرتبط با بله; Liver Cancer; Gene Regulation; Oncogene; Tumor Formation; Dlk1; delta-like protein/preadipocyte factor 1/fetal antigen 1 delta-like protein/preadipocyte factor 1/fetal antigen 1; EpCAM; epithelial cell adhesion molecule; HB; hepatoblastoma; HCC; hepatocel
Arsenic-induced cutaneous hyperplastic lesions are associated with the dysregulation of Yap, a Hippo signaling-related protein
Keywords: پروتئین مرتبط با بله; Yap; Yes-associated protein; Mst1/2; mammalian STE20-like kinase 1/2; Sav1; Salvador homolog 1; LATS1/2; large tumor suppressor kinase 1/2; MOB1; MOB kinase activator 1A; TAZ; transcriptional co-activator with PDZ-binding motif; TEAD; Tea-domain; BCC; bas
AMOTL2 interaction with TAZ causes the inhibition of surfactant proteins expression in lung cells
Keywords: پروتئین مرتبط با بله; TAZ; Transcriptional co-Activator with PDZ-binding motif; AMOTL2; Angiomotin-like 2 protein; TTF-1; Thyroid Transcription Factor-1; YAP; Yes-Associated Protein; GST; glutathione-S transferase; MLE; mouse lung epithelial; HA; hemagglutinin; CMV; cytomegalo
3D microtissue-derived human stem cells seeded on electrospun nanocomposites under shear stress: Modulation of gene expression
Keywords: پروتئین مرتبط با بله; Amorphous calcium phosphate; Adipose-derived stem cell; Composite; Osteogenesis; Yes-associated protein; Stiffness;