کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5501414 | 1534849 | 2017 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Skeletal muscle morphology and regulatory signalling in endurance-trained and sedentary individuals: The influence of ageing
ترجمه فارسی عنوان
مورفولوژی عضله اسکلتی و سیگنالینگ قانونی در افراد با استقامت و نشاطی: تاثیر پیری
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کلمات کلیدی
ribosomal protein large P0HGFNFkBTCF7L2TGFMuRF1HspRPLP0muscle RING-finger protein-1PerimysiumSATGAPDHMaster athletesTNFMCPinflammation - التهاب( توروم) interleukin - اینترلوکینIntramuscular connective tissue - بافت همبند داخل عضلانیSubcutaneous adipose tissue - بافت چربی زیر پوستیtransforming growth factor - تبدیل فاکتور رشدforkhead Box O - جعبه O جعبه Ostandard error - خطای استانداردHepatocyte growth factor - عامل رشد هپاتوسیتtranscription factor 7-like 2 - فاکتور رونویسی 7 مانند 2tumor necrosis factor - فاکتور نکروز تومورnuclear factor kappa-light-chain-enhancer of activated B cells - فاکتور هسته ای kappa-light-chain-enhancer از سلول های B فعال شده استFoxO - فاکسوLAM - لامLaminin - لامینینHeat shock protein - پروتئین شوک حرارتmonocyte chemoattractant protein - پروتئین شیمیایی monocyte chemoattractantCollagen - کلاژنSarcopenia - کم ماهیچگیcol - کولglyceraldehyde 3-phosphate dehydrogenase - گلیسرولیدید 3-فسفات دهیدروژنازReceptor - گیرنده
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Muscle mass in humans is inversely associated with circulating levels of inflammatory cytokines, but the interaction between ageing and training on muscle composition and the intra-muscular signalling behind inflammation and contractile protein synthesis and degradation is unknown. We studied 15 healthy life-long endurance runners, 12 age-matched untrained controls, 10 young trained and 12 young untrained individuals. Thigh muscle composition was investigated by magnetic resonance imaging (MRI), where non-contractile intramuscular tissue (NCIT) area (fat and connective tissue) was found to be greater in older but lower in trained individuals. Subcutaneous adipose tissue was also lower in trained individuals but was not affected by age. In vastus lateralis biopsies, no influence of age or training was found on levels of endomysial collagen, determined by Sirius Red and Collagen III staining, whereas perimysial organisation tended to be more complex in older individuals. No clear difference with training was seen on intramuscular inflammatory signalling, whereas lower protein levels of NFkB subunits p105, p50 and p65 were observed with ageing. Gene expression of IL6 and TNFα was not different between groups, while IL1-receptor and TNFα-receptor1 levels were lower with age. Myostatin mRNA was lower in older and trained groups, while expression of MuRF1 was lower in trained individuals and FoxO3 expression was greater in aged groups. The association of increased muscle NCIT with age-associated muscle loss in humans is not accompanied by any major alterations in intramuscular signalling for inflammation, but rather by direct regulatory factors for protein synthesis and proteolysis in skeletal muscle.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 93, July 2017, Pages 54-67
Journal: Experimental Gerontology - Volume 93, July 2017, Pages 54-67
نویسندگان
U.R. Mikkelsen, J. Agergaard, C. Couppé, J.F. Grosset, A. Karlsen, S.P. Magnusson, P. Schjerling, M. Kjaer, A.L. Mackey,