کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4178333 1276488 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
At-Risk Variant in TCF7L2 for Type II Diabetes Increases Risk of Schizophrenia
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
At-Risk Variant in TCF7L2 for Type II Diabetes Increases Risk of Schizophrenia
چکیده انگلیسی

BackgroundSchizophrenia is associated with increased risk of type II diabetes and metabolic disorders. However, it is unclear whether this comorbidity reflects shared genetic risk factors, at-risk lifestyle, or side effects of antipsychotic medication.MethodsEleven known risk variants of type II diabetes were genotyped in patients with schizophrenia in a sample of 410 Danish patients, each matched with two healthy control subjects on sex, birth year, and month. Replication was carried out in a large multinational European sample of 4089 patients with schizophrenia and 17,597 controls (SGENE+) using Mantel–Haenszel test.ResultsOne type II diabetes at-risk allele located in TCF7L2, rs7903146 [T], was associated with schizophrenia in the discovery sample (p = .0052) and in the replication with an odds ratio of 1.07 (95% confidence interval 1.01–1.14, p = .033).ConclusionThe association reported here with a well-known diabetes variant suggests that the observed comorbidity is partially caused by genetic risk variants. This study also demonstrates how genetic studies can successfully examine an epidemiologically derived hypothesis of comorbidity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 70, Issue 1, 1 July 2011, Pages 59–63
نویسندگان
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