A Bacterial Reporter System for the Evaluation of Antisense Oligodeoxynucleotides Directed against Human Papillomavirus Type 16 (HPV-16)

A correlation was observed between bacterial CFP downregulation with the HPV-16 E6/E7 mRNA downregulation and the inhibition of anchorage-independent growth of HPV-16 containing cells suggesting that inhibition of HPV-16 E6/E7 expression by AS-ODNs directed against 410-445 target in cervical tumor cells can be tested in bacterial models.