دانلود مقالات ISI درباره Oligodeoxynucleotides + ترجمه فارسی

گیرنده های شناسایی الگوی هدف برای کشف مولکول های کوچک مولکولی کوچک

Targeting pattern-recognition receptors to discover new small molecule immune modulators

Keywords: Pattern-recognition receptors (PRRs); Toll-like receptors (TLRs); RIG-I-like receptors (RLRs); NOD-like receptors (NLRs); Small molecule modulators; BIR; baculovirus inhibitor repeat; CARD; caspase recruitment domains; CFS; chronic fatigue syndrome; CLR;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

غلبه بر موانع تحویل دارو چشم با استفاده از نیروهای فیزیکی

Overcoming ocular drug delivery barriers through the use of physical forces

Keywords: AMD; age-related macular degeneration; BAB; blood-aqueous barrier; BC; Bruch's-choroid; Bev; bevacizumab; BRB; blood-retinal barrier; BSA; bovine serum albumin; Dex; dexamethasone; DSP; dexamethasone sodium phosphate; DMPC; dimyristoyl-phosphatidylcholine

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

پیشرفت های اخیر در کاربرد فناوری نانو برای ایمونوتراپی سرطان

Recent advances in applying nanotechnologies for cancer immunotherapy

Keywords: Cancer Immunotherapy; Nanoparticles; Antigenic Peptides; Oligodeoxynucleotides; Immunomodulatory siRNA; Antigenic pDNA; Immune check point inhibitor;

دانلود رایگان متن کامل مقاله ISI 82 صفحه سال انتشار : 2018 سفارش ترجمه

Organic matrices, ionic liquids, and organic matrices@nanoparticles assisted laser desorption/ionization mass spectrometry

Keywords: Organic matrices; Nanoparticles; Ionic liquids; Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS); Surface enhanced laser desorption/ionization mass spectrometry (SELDI-MS); 9-AA; 9-aminoacridine; APCI; atmospheric pressure chemical

دانلود رایگان متن کامل مقاله ISI 144 صفحه سال انتشار : 2017 سفارش ترجمه

بررسی اثربخشی و ریسک درمانهای ضد دیابتی: تجویز داروهای سنتی - تجدیدنظر مکانیکی برای درک نحوه عملکرد آنها

Efficacy and risk profile of anti-diabetic therapies: Conventional vs traditional drugs-A mechanistic revisit to understand their mode of action

Keywords: GLUT; Glucose transporter; T1DM; Type-1 diabetes mellitus; T2DM; Type-2 diabetes mellitus; PKB/Akt; protein kinase B; GSK-3; glycogen synthase kinase-3; PGC-1α; peroxisome proliferator-activated receptor gamma coactivator-1α; FOXO; forkhead box O; VLDL;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2016 سفارش ترجمه

Knockdown of zif268 in the Posterior Dorsolateral Striatum Does Not Enduringly Disrupt a Response Memory of a Rewarded T-Maze Task

Keywords: aDLS; anterior dorsolateral striatum; aDMS; anterior dorsomedial striatum; ANOVA; analysis of variance; A-O; 'action-outcome'; BLA; Basolateral Amygdala; IEG; Immediate Early Genes; NAc; Nucleus Accumbens; ODN; Oligodeoxynucleotides; pDLS; posterior d

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Iron Oxide Nanoparticles (IONPs) with potential applications in plasmid DNA isolation

Keywords: IONPs; Iron Oxide Nanoparticles; APTES; (3-aminopropyl)triethoxysilane; ODN; oligodeoxynucleotides; pDNA; plasmid deoxyribonucleic acid; Tris; tris(hydroxymethyl)aminomethane; Plasmid DNA isolation; Functionalized iron oxide nanoparticles; Coprecipitation

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2018 سفارش ترجمه

Atlanto-occipital catheterization of young rats for long-term drug delivery into the lumbar subarachnoid space combined with in vivo testing and electrophysiology in situ

Keywords: Spinal catheterization; Intrathecal delivery; Young animals; Genetic material; Oligodeoxynucleotides; Local treatment; Spinal cord electrophysiology; Sensory interneurons; Behavioral testing; Peripheral sensitivity;

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2017 سفارش ترجمه

Delivery methods to increase cellular uptake and immunogenicity of DNA vaccines

Keywords: HIV; human immunodeficiency virus; AIDS; acquired immunodeficiency syndrome; HCV; hepatitis C virus; LAV; live attenuated viral vaccines; VLP; virus-like particles; IM; intramuscular; ID; intradermal; DC; dendritic cells; APC; antigen presenting cells; Th

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

N-glycosylation-mutated HCV envelope glycoprotein complex enhances antigen-presenting activity and cellular and neutralizing antibody responses

Keywords: Antigen presenting cell; APC; cell culture-derived HCV; HCVcc; Cytotoxic T lymphocyte; CTL; enzyme-linked immunospot assay; ELISPOT; half-maximal effective concentration; EC50; Hepatitis C Virus; HCV; HCV pseudo particles; HCVpp; interleukin; IL; interfer

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2016 سفارش ترجمه

One-step synthesized immunostimulatory oligonucleotides-functionalized quantum dots for simultaneous enhanced immunogenicity and cell imaging

Keywords: CpG motif; Quantum dots; Immunostimulation; Oligodeoxynucleotides; Cell imaging;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Co-delivery of doxorubicin and siRNA by a simplified platform with oligodeoxynucleotides as a drug carrier

Keywords: Oligodeoxynucleotides; Intercalation; Intracellular co-delivery; Charge-reversal; Lysosomal escape;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with 18F-incorporated oligodeoxynucleotides

Keywords: Oligodeoxynucleotides; Positron emission tomography imaging; Pharmacokinetics; 18F-labeling;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Intraperitoneal and subcutaneous injections of the TLR9 agonist ODN 1668 in rats: Brain inflammatory responses are related to peripheral IL-6 rather than interferons

Keywords: AP; area postrema; COX-2; cyclooxygenase-2; CpG; cytosine-phosphate-guanosine dinucleotides; CVOs; circumventricular organs; ELISA; enzyme-linked immuno-sorbent assay; IFN; interferon; IHC; immunohistochemistry; IκBα; inhibitor kappa B alpha; IL; in

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Coordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions

Keywords: 8-oxoG or Go; 7,8-dihydro-8-oxoguanine; 9-1-1; Rad9-Rad1-Hus1; AP; apurinic/apyrimidinic; APE1; AP-endonuclease 1; BSA; bovine serum albumin; BER; base excision repair; BstMutY; Bacillus stearothermophilus MutY; Ec-cMutY; Escherichia coli MutY cat

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Progress in microRNA delivery

Keywords: AMO; anti-miRNA oligonucleotides; APP; amyloid precursor protein; BBB; blood-brain barrier; bp; base pairs; CNS; central nervous system; CSC; cancer stem cell; DDAB; dimethyldioctadecylammonium bromide; DGCR8; DiGeorge syndrome critical region gene; DNA

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Binding and elution behavior of small deoxyribonucleic acid fragments on a strong anion-exchanger multimodal chromatography resin

Keywords: Ion-exchange chromatography; Plasmid; Nucleotide; Single-stranded DNA; Double-stranded DNA; Oligodeoxynucleotides

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Efficacy evaluation of live Escherichia coli expression Brucella P39 protein combined with CpG oligodeoxynucleotides vaccine against Brucella melitensis 16M, in BALB/c mice

Keywords: Adjuvant; Brucella; E. coli; Oligodeoxynucleotides; Protection

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Immunoprotective activity of a Salmonid Alphavirus Vaccine: Comparison of the immune responses induced by inactivated whole virus antigen formulations based on CpG class B oligonucleotides and poly I:C alone or combined with an oil adjuvant

Keywords: NAbs; neutralizing antibodies; Ag; antigen; ODNs; oligodeoxynucleotides; TLR; toll-like receptor; APC; antigen-presenting cells; PRRs; pattern recognition receptors; RPP; relative percent protection; HK; head kidney; RT-qPCR; reverse transcriptase quantit

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts

Keywords: MMS; methylmethane sulfonate; ds; double-stranded; ss; single-stranded; ODN; oligodeoxynucleotides; α-KGFdiO; α-ketoglutarate Fe(II) dioxygenase; MEFs; mouse embryonic fibroblasts; mESCs; mouse embryonic stem cells; DNA repair; AlkB homologs; Fe(II)/α-

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Post-training disruption of Arc protein expression in the anterior cingulate cortex impairs long-term memory for inhibitory avoidance training

Keywords: Activity-regulated-cytoskeletal-associated protein; Memory consolidation; Anterior cingulate cortex; Immediate-early genes; Oligodeoxynucleotides; Aversive memory;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis and immunological activities of novel agonists of toll-like receptor 9

Keywords: Toll-like receptor 9; Oligodeoxynucleotides; Immune stimulatory; T helper 1-type immune response

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Stability of responsive polymer-protein bioconjugates

Keywords: AADG; acrylamide-2-deoxy-D-glucose; AIBN2; 2′-azobisisobutyronitrile; ATRP; atom transfer radical polymerization; CDs; cyclodextrins; CRL; Candida-rugosa lipase; CRP; controlled radical polymerization; DMSO; dimethyl sulphoxide; EDCI; 1-ethyl-3-(3-dieth

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2010 سفارش ترجمه

The assembly of a short linear natural cytosine-phosphate-guanine DNA into dendritic structures and its effect on immunostimulatory activity

Keywords: CpG motif; Immunostimulatory activity; Oligodeoxynucleotides; Toll-like receptor 9; Dendrimer

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Approaches to enhancing immune responses stimulated by CpG oligodeoxynucleotides

Keywords: CpG DNA; Oligodeoxynucleotides; Toll-like receptors; Polyphosphazenes; Formulation; Delivery

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Liposome encapsulated polyethylenimine/ODN polyplexes for brain targeting

Keywords: In vivo gene delivery; Oligodeoxynucleotides; PEGylated liposomes; Polyethylenimine; Blood-brain barrier

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity

Keywords: Adjuvant; Innate defence regulator peptide; Host defense peptide; CpG DNA; Oligodeoxynucleotides; Toll-like receptors; Formulation

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Enhanced Th2 immunity after DNA prime–protein boost immunization with amyloid β (1–42) plus CpG oligodeoxynucleotides in aged rats

Keywords: Alzheimer's disease; Prime-boost strategy; Oligodeoxynucleotides; Adjuvant; Th2 response

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Predicting ultraviolet spectrum of single stranded and double stranded deoxyribonucleic acids

Keywords: Extinction coefficient; Oligodeoxynucleotides; Hypochromism; Nearest-neighbor model; DNA; Ultraviolet spectrum;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

A combination of Lox-1 and Nox1 regulates TLR9-mediated foam cell formation

Keywords: TLRs; toll-like receptors; ODN; oligodeoxynucleotides; SRs; scavenger receptors; oxLDL; oxidized low-density lipoprotein; Lox-1; lectin-like oxLDL receptor-1; LPS; lipopolysaccharides; ROS; reactive oxygen species; Nox; NADPH oxidase; CQ; Chloroquine; DCF

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

An optimized electrofusion-based protocol for generating virus-specific human monoclonal antibodies

Keywords: mAb; monoclonal antibody; EBV; Epstein-Barr virus; ODNs; oligodeoxynucleotides; PBMC; peripheral blood mononuclear cells; mIL-6; murine interleukin-6; hTERT; human telomerase catalytic subunit; PEG; polyethylene glycol; RSV; respiratory syncytial virus.;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Novel monolithic poly(phenyl acrylate-co-1,4-phenylene diacrylate) capillary columns for biopolymer chromatography

Keywords: Phenyl acrylate (PA); 1,4-Phenylene diacrylate (PDA); Monolithic capillary columns; Micro-HPLC; Proteins; Oligodeoxynucleotides

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Involvement of Na+-Ca2+ exchanger on metabotropic glutamate receptor 1-mediated [Ca2+]i transients in rat cerebellar Purkinje neurons

Keywords: Na+-Ca2+ exchanger; NCX; metabotropic glutamate receptor 1; mGluR1; cerebellar Purkinje neuron; 3,5-dihydroxyphenylglycine; DHPG; AMPAR; AMPA receptor; AS-oligos; antisense oligodeoxynucleotides; BSA; bovine serum albumin; [Ca2+]i; intracellular Ca2+ co

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Sensitive determination of oligodeoxynucleotides by anodic adsorptive stripping voltammetry at surface-roughened glassy carbon electrode in the presence of copper

Keywords: Glassy carbon electrode; Oligodeoxynucleotides; Purine base residue–copper(I) complex; Surface morphology

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Microanalysis of oligodeoxynucleotides by cathodic stripping voltammetry at amalgam-alloy surfaces in the presence of copper ions

Keywords: Gold amalgam-alloy electrode; Platinum amalgam-alloy electrode; Silver amalgam-alloy electrode; Copper amalgam-alloy electrode; Oligodeoxynucleotides; Purine base residue–copper(I) complex; Analysis of microliter volumes of oligodeoxynucleotides

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Hammerhead ribozymes with cleavage site specificity for NUH and NCH display significant anti-hepatitis C viral effect in vitro and in recombinant HepG2 and CCL13 cells

Keywords: Hammerhead ribozymes; Oligodeoxynucleotides; Hepatitis C virus (HCV); Experimental antiviral treatmentNCH/NUH C, cytidine; H, any nucleotide except guanosine; N, any nucleotide; U, uridine

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

A Bacterial Reporter System for the Evaluation of Antisense Oligodeoxynucleotides Directed against Human Papillomavirus Type 16 (HPV-16)

Keywords: Antisense; Papillomavirus; Green fluorescent protein; Oligodeoxynucleotides; Therapeutic oligonucleotides;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Atomic force microscopy characterization of synthetic pyrimidinic oligodeoxynucleotides adsorbed onto an HOPG electrode under applied potential

Keywords: Oligodeoxynucleotides; ODN; HOPG; AFM; Atomic force microscopy; DNA-biosensor

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Adsorption of synthetic homo- and hetero-oligodeoxynucleotides onto highly oriented pyrolytic graphite: Atomic force microscopy characterization

Keywords: AFM; Oligodeoxynucleotides; ODN; Adsorption; DNA-biosensor; Hydrophobic interactions;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Antisense strategies in degenerative joint diseases: Sense or nonsense?

Keywords: Oligodeoxynucleotides; RNAi; Ribozymes; Drug design; Cartilage destruction; Osteoarthritis; Rheumatoid arthritis

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2006 سفارش ترجمه

Immunostimulatory oligodeoxynucleotides induce dolphin neutrophil NADPH-oxidase activation in a CpG-independent but phosphorothioate backbone-dependent manner

Keywords: Dolphin; Neutrophils; NADPH-oxidase; Oligodeoxynucleotides; Phosphorothioate backbone;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Bacterial CpG induces hyper-IgM production in CD27+ memory B cells in primary biliary cirrhosis

Keywords: AMA; antimitochondrial antibody; CFSE; 5-carboxyfluorescein diacetate succinimidyl ester; MFI; mean fluorescence intensity; ODN; oligodeoxynucleotides; PBC; primary biliary cirrhosis; PBMC; peripheral blood mononuclear cell; PDC-E2; pyruvate dehydrogenase

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Candida albicans double-stranded DNA can participate in the host defense against disseminated candidiasis

Keywords: Candida albicans infection; Candida albicans DNA; Macrophages; Cytokines; CFU; colony-forming units; CQ; chloroquine; CT DNA; calf thymus DNA; dsDNA; double-stranded DNA; IFN; interferon; IL; interleukin; i.p.; intraperitoneally; ODN; oligodeoxynucleotide

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

The immunostimulatory activity of CpG oligonucleotides on microglial N9 cells is affected by a polyguanosine motif

Keywords: ODN; oligodeoxynucleotides; PS; phosphothioate; PE; phosphodiester; TLR9; Toll-like receptor 9; FCS; fetal calf serum; PBS; phosphate-buffered saline; FITC; fluorescein isothiocyanate; DAPI; 4′,6′-diamidino-2-phenylindole hydrochloride; PFA; paraforma

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Determination of picogram quantities of oligodeoxynucleotides by stripping voltammetry at mercury modified graphite electrode surfaces

Keywords: Pyrolytic graphite electrode; Glassy carbon electrode; Mercury film electrodes; Oligodeoxynucleotides; Purine base residue-copper(I) complex; Surface roughness;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Characterization and quantification of Bcl-2 antisense G3139 and metabolites in plasma and urine by ion-pair reversed phase HPLC coupled with electrospray ion-trap mass spectrometry

Keywords: HFIP; 1,1,1,3,3,3-hexafluoro-2-propanol; CVs; coefficients of variations; CID; collision induced dissociation; CIVI; continuous intravenous infusion; ESI; electrospray ionisation; ELISA; enzyme-linked immunosorbent assay; IP-RP-HPLC; ion-pair reversed pha

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2005 سفارش ترجمه

Molecular characterization of a novel pattern recognition protein from nonspecific cytotoxic cells: Sequence analysis, phylogenetic comparisons and anti-microbial activity of a recombinant homologue

Keywords: Nonspecific cytotoxic cells (NCC); Anti-microbial proteins; Oligodeoxynucleotides; Lysine box motif; Innate immunity; Pattern recognition receptors; Natural killer cells;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2005 سفارش ترجمه