کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5537416 1402334 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Delivery methods to increase cellular uptake and immunogenicity of DNA vaccines
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Delivery methods to increase cellular uptake and immunogenicity of DNA vaccines
چکیده انگلیسی
DNA vaccines are ideal candidates for global vaccination purposes because they are inexpensive and easy to manufacture on a large scale such that even people living in low-income countries can benefit from vaccination. However, the potential of DNA vaccines has not been realized owing mainly to the poor cellular uptake of DNA in vivo resulting in the poor immunogenicity of DNA vaccines. In this review, we discuss the benefits and shortcomings of several promising and innovative non-biological methods of DNA delivery that can be used to increase cellular delivery and efficacy of DNA vaccines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 34, Issue 46, 4 November 2016, Pages 5488-5494
نویسندگان
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