Co-delivery of doxorubicin and siRNA by a simplified platform with oligodeoxynucleotides as a drug carrier

- CGA-ODNs were introduced to load Dox without any modification of carriers or drugs and five Dox could be loaded in one CGA-ODN.
- Based on electrostatic interaction, Dox and siRNA could be co-loaded. Cellular internalization of PDR demonstrated the co-loading and co-delivery effect with mono-loading process.
- CLSM images confirmed the targeted cellular uptake and successful lysosomal escape of siRNA and Dox. Nuclear localization of Dox was also observed clearly.
- In vitro drug release and cellular uptake confirmed the pH sensitivity of CPN, another mechanism of internalization.