Cardiorespiratory Response to Exercise Testing in Individuals With Alzheimer's Disease

Billinger SA, Vidoni ED, Honea RA, Burns JM. Cardiorespiratory response to exercise testing in individuals with Alzheimer's disease.ObjectiveTo examine exercise testing response in Alzheimer's disease (AD) and possible disease-related change over time.DesignRetrospective assessment of a 2-year observational study.SettingUniversity medical center.ParticipantsIndividuals without dementia (n=50) and with AD (n=31).InterventionsNot applicable.Main Outcome MeasuresParticipants underwent a clinical dementia evaluation and performed an incremental exercise test using a treadmill and the modified Bruce protocol at baseline and at a 2-year follow-up. We examined oxygen consumption, minute ventilation, heart rate, and ventilatory equivalents for oxygen and carbon dioxide at submaximal and peak exercise intensities to determine whether the measures were different between groups or over time.ResultsParticipants with AD and those without dementia performed similarly at submaximal effort, and both groups showed similar changes in exercise response over 2 years. However, nondemented individuals had consistently higher values of oxygen consumption (P≤.02) and minute ventilation at peak effort at baseline (P=.003).ConclusionsIndividuals with AD demonstrate physiologic responses to submaximal exercise effort that are not significantly different than individuals without dementia. However, differences are apparent at the extreme of effort.