کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3453814 1595938 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antioxidant and antidiabetic activities of the seed and leaf extracts of Chrysophyllum albidum
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Antioxidant and antidiabetic activities of the seed and leaf extracts of Chrysophyllum albidum
چکیده انگلیسی

ObjectiveTo investigate the antioxidant and antidiabetic activities of the seed and leaf extracts of Chrysophyllum albidum (C. albidum).MethodsAfter assessing the in vitro ferric reducing power and hydrogen peroxide scavenging activities as well as the flavonoid and flavanol contents, the seed and leaf extracts were administered to diabetic rats for 7 days. The animals were sacrificed and serum was obtained for the determination of blood glucose level while liver sample was used for the quantification of glycogen level as well as lipidic peroxidation and catalase activity.ResultsSeed and leaf extracts of C. albidum showed ferric reducing activity and very high hydrogen peroxide scavenging potential. After the administration of treatment in diabetic rats, there was a significant decrease (P <0.05) in blood sugar level and a significant increase (P<0.05) in liver glycogen level in Groups 3 and 4 animals administered the leaf and seed extracts respectively compared to Group 1 (the negative control). Also, catalase activity and malondialdehyde levels increased in Groups 3 and 4 administered the extracts compared to Group 1 animals (the negative control). Flavonoids and flavanol were present and significantly higher (P<0.05) in the leaf than seed extract. In all, the leaf extract showed the greatest activities.ConclusionsThese results suggest that the leaf and seed extracts of C. albidum possess both in vitro and in vivo antioxidant activities in scavenging free radicals as well as antidiabetic activity, and as such, a potentially important compound in antidiabetic drug discovery.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Pacific Journal of Tropical Disease - Volume 6, Issue 8, August 2016, Pages 642–649
نویسندگان
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