کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3569 175 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Power input correlation to characterize the hydrodynamics of cylindrical orbitally shaken bioreactors
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Power input correlation to characterize the hydrodynamics of cylindrical orbitally shaken bioreactors
چکیده انگلیسی

Disposable cylindrical shaken bioreactors using plastic bags or vessels represent a promising alternative to stainless steel bioreactors, because they are flexible, cost-effective and can be pre-sterilized. Unlike conventional well-established steel bioreactors, however, such disposable bioreactor systems have not yet been precisely characterized. Thus, the aim of this current work is to introduce a new power input correlation as a potential means to characterize the hydrodynamics of these new systems. A set of relevant power input variables was defined and transformed into dimensionless numbers by using the Buckingham's π-Theorem. These numbers were then experimentally varied to quantify the relationship among the numbers. A simple correlation was generated for the power input with seven variables. The application of this new correlation was validated using 200 L and 2000 L orbitally shaken bioreactors. In conclusion, the proposed correlation is a useful tool to predict the power input and hydrodynamics during cell cultivation in cylindrical shaken bioreactors of all scales.


► Introduction of a new power input correlation for disposable orbitally shaken bioreactors.
► Application validated using 200 L and 2000 L orbitally shaken bioreactors.
► Prediction of power input and hydrodynamics in cylindrical shaken bioreactors of all scales.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Engineering Journal - Volume 65, 15 June 2012, Pages 63–69
نویسندگان
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