کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
35985 | 45117 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cell cycle model for recombinant Pichia pastoris during glycerol fed-batch cultivation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A cell cycle model is proposed for methylotrophic yeast Pichia pastoris grown on glycerol during fed-batch cultivation. Morphological differentiation of cells, such as unbudded daughter cell, unbudded parent cell and budding cell, is depicted by the model. During the cyclic growth, cells in different cycling period are assumed to undergo sequential shifting dominantly. The input of the cell cycle model is the specific growth rate, which is calculated from the macrokinetic model proposed previously. The cell cycle related variables, such as the fraction of budding cells and the cell density are then simulated. Model validation is carried out with the experimental data of off-line assays.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Process Biochemistry - Volume 42, Issue 5, May 2007, Pages 828–833
Journal: Process Biochemistry - Volume 42, Issue 5, May 2007, Pages 828–833
نویسندگان
L. Jia, J.Q. Yuan,