Integrated Circuit-Based Biofabrication with Common Biomaterials for Probing Cellular Biomechanics

Recent advances in bioengineering have enabled the development of biomedical tools with modifiable surface features (small-scale architecture) to mimic extracellular matrices and aid in the development of well-controlled platforms that allow for the application of mechanical stimulation for studying cellular biomechanics. An overview of recent developments in common biomaterials that can be manufactured using integrated circuit-based biofabrication is presented. Integrated circuit-based biofabrication possesses advantages including mass and diverse production capacities for fabricating in vitro biomedical devices. This review highlights the use of common biomaterials that have been most frequently used to study cellular biomechanics. In addition, the influence of various small-scale characteristics on common biomaterial surfaces for a range of different cell types is discussed.

TrendsCommon biomaterials for probing cellular biomechanics are described.Integrated circuit (IC)-based biofabrication methods for constructing small-scale devices are described.The development of small-scale structures for regulating cell behaviors is presented.Cell micropatterning technology for biological applications is presented.