کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
36909 | 45282 | 2015 | 9 صفحه PDF | دانلود رایگان |
• Insulation of parts and functional modules from their context is a major challenge.
• Parts engineering and circuit design are both important in solving context-dependence.
The ability to link systems together such that they behave as predicted once they interact with each other is an essential requirement for the forward-engineering of robust synthetic biological circuits. Unfortunately, because of context-dependencies, parts and functional modules often behave unpredictably once interacting in the cellular environment. This paper reviews recent advances toward establishing a rigorous engineering framework for insulating parts and modules from their context to improve modularity. Overall, a synergy between engineering better parts and higher-level circuit design will be important to resolve the problem of context-dependence.
Journal: - Volume 33, Issue 2, February 2015, Pages 111–119