کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
370589 621876 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
l-Carnitine supplementation improves the behavioral symptoms in autistic children
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
l-Carnitine supplementation improves the behavioral symptoms in autistic children
چکیده انگلیسی

l-Carnitine was proposed as a potential treatment for patients diagnosed with autism to ameliorate the behavioral symptoms associated with the disease. Thirty children diagnosed with autism were randomly assigned to receive (100 mg/kg bodyweight/day) of liquid l-carnitine (n = 16) or placebo (n = 14) for 6 months. Measurements included changes in childhood autism rating scale (CARS) form and free and total carnitine levels using tandem mass spectrometry. Results showed significant improvement in CARS scores (P-groups <0.001) and (P-overtime = 0.006), with statistically significant differences in free carnitine levels (P = 0.027) and total carnitine levels (P = 0.036). There was no correlation between baseline free and total carnitine levels with changes in CARS scores from zero to 6 months (r > 0.5, P > 0.05) and generally l-carnitine therapy was well tolerated. In conclusion, l-carnitine therapy (100 mg/kg bodyweight/day) administered for 6 months significantly improved the autism severity, but subsequent studies are recommended.


► Significant differences were found in free and total carnitine levels after therapy.
► Clinically, l-carnitine supplementation improves autism severity.
► l-Carnitine therapy was well tolerated.
► l-Carnitine supplements may be given as part of autism treatment regimen.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Autism Spectrum Disorders - Volume 7, Issue 1, January 2013, Pages 159–166
نویسندگان
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