کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
370777 | 621883 | 2011 | 7 صفحه PDF | دانلود رایگان |
Dysfunction of the prefrontal cortex has been previously reported in individuals with Asperger's disorder. In the present study, we used multi-channel near-infrared spectroscopy (NIRS) to detect changes in the oxygenated hemoglobin concentration ([oxy-Hb]) during two verbal fluency tasks. The subjects were 20 individuals with Asperger's disorder and 18 age- and IQ-matched healthy controls. The relative [oxy-Hb] in the prefrontal cortex was measured during the category and letter fluency tasks. The mean total [oxy-Hb] during the category fluency task did not differ significantly between the groups; however, during the letter fluency task, the mean [oxy-Hb] in persons with Asperger's disorder was significantly lower than that in controls. These results suggested task-relevant or task-specific prefrontal dysfunction in persons with Asperger's disorder.
Research highlights
► The mean total [oxy-Hb] measured with NIRS during the category fluency task did not differ significantly between persons with Asperger's disorder and controls.
► During the letter fluency task, the mean [oxy-Hb] in persons with Asperger's disorder was significantly lower than that in controls.
► Task-relevant or task-specific prefrontal dysfunction exists in persons with Asperger's disorder.
Journal: Research in Autism Spectrum Disorders - Volume 5, Issue 3, July–September 2011, Pages 1187–1193