Atypical modulation of face-elicited saccades in autism spectrum disorder in a double-step saccade paradigm

Atypical development of face processing is a major characteristic in autism spectrum disorder (ASD), which could be due to atypical interactions between subcortical and cortical face processing. The current study investigated the saccade planning towards faces in ASD. Seventeen children with ASD and 17 typically developing (TD) children observed a pair of upright or inverted face configurations flashed sequentially in two different spatial positions. The reactive saccades of participants were recorded by eye-tracking. The results did not provide evidence of overall impairment of subcortical route in ASD, However, the upright, but not the inverted, face configuration modulated the frequency of vector sum saccades (an index of subcortical control) in TD, but not in ASD. The current results suggest that children with ASD do not have overall impairment of the subcortical route, but the subcortical route may not be specialized to face processing.

Research highlights
► Atypical face processing is characteristic in autism spectrum disorder (ASD).
► We analyzed the pattern of face-elicited saccades.
► ASD did not show overall impairment, but did not show face-relevant adaptation of the saccade.
► Results suggest atypical interaction between the subcortical and cortical face processing in ASD.