کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
37123 45313 2013 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
From gene switches to mammalian designer cells: present and future prospects
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
From gene switches to mammalian designer cells: present and future prospects
چکیده انگلیسی

Nature has evolved a treasury of biological molecules that are logically connected to networks, enabling cells to maintain their functional integrity. Similar to electronic circuits, cells operate as information-processing systems that dynamically integrate and respond to distinct input signals. Synthetic biology aims to standardize and expand the natural toolbox of biological building blocks to engineer novel synthetic networks in living systems. Mammalian cells harboring integrated designer circuits could work as living biocomputers that execute predictable metabolic and therapeutic functions. This review presents design principles of mammalian gene circuits, highlights recent developments, and discusses future challenges and prospects.


► Comprehensive overview of trigger-inducible transgene control switches.
► Construction of synthetic biology-inspired, multicomponent designer circuits.
► Future cell-based treatment strategies using prosthetic designer networks.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 31, Issue 3, March 2013, Pages 155–168
نویسندگان
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