کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3803843 1244966 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dermatological pharmacology: systemic drugs
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Dermatological pharmacology: systemic drugs
چکیده انگلیسی

In recent years there has been an evolution in the systemic therapy of skin disease, in particular immunosuppressive agents, retinoids and, most lately, biological drugs and new classes of drugs for advanced skin cancer. Developments in drug monitoring include measurement of thiopurine methyl transferase enzyme activity before prescribing azathioprine, to screen for patients at risk of severe bone marrow depression, and monitoring recipients of methotrexate with procollagen III peptide or Fibroscans to detect hepatic fibrosis. Biologics including anti-tumour necrosis factor α therapy offer a new and effective treatment for severe psoriasis in patients who have failed to respond to conventional systemic drugs, but risks include reactivation of tuberculosis. Oral retinoid therapy has expanded to include alitretinoin, a new oral drug for severe hand eczema, and stringent requirements have been introduced for females treated with isotretinoin due to the high risk of birth deformity which is common to these drugs. It is important that physicians are aware of the adverse effects of treatment and that patients are carefully selected screened and monitored to minimize any risk.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medicine - Volume 41, Issue 6, June 2013, Pages 330–333
نویسندگان
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