کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3804542 | 1245076 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Coeliac disease
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Coeliac disease is a common condition that may present at any age after weaning with a spectrum of symptoms ranging from none at all, through mild irritable bowel type complaints, to weight loss and diarrhoea. Patients with coeliac disease have an increased risk of autoimmunity. The majority of patients express either HLA DQ2 or 8 haplotypes, but other genetic factors required for disease expression remain undiscovered. IgA antibodies against tissue transglutaminase have a high specificity but a sensitivity as low as 80% for detection of the condition and intestinal biopsy remains the diagnostic standard. Treatment with a strict gluten-free diet is mandatory and leads to a reduced risk of associated complications that include low bone mineral density and intestinal malignancy. The majority of patients thought to be 'refractory' to dietary treatment are found to have gluten sources in the diet, but a small proportion harbour atypical monoclonal intraepithelial lymphocytes and are at risk of developing intestinal lymphoma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medicine - Volume 35, Issue 4, April 2007, Pages 226-230
Journal: Medicine - Volume 35, Issue 4, April 2007, Pages 226-230
نویسندگان
Jeremy Woodward,