کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3813357 1408854 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recent advances in the management of atypical meningiomas
ترجمه فارسی عنوان
پیشرفت های اخیر در مدیریت مننژیم های آتیپیک
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Based on the 2007 WHO classification, the proportion of atypical meningiomas has steeply increased. Complete resection is usually considered curative, however, the recurrence rate remains high. The treatment of more aggressive meningiomas remains problematic. We performed a literature review via the PubMed database with specific attention to radiological, pathological, genetic and molecular aspects particular to WHO grade II meningiomas and current therapeutic strategies. We also reviewed the role of surgery and summarized the results of the principal studies dealing with adjuvant strategies based on the most recent evidence. Adjuvant radiotherapy, administered as stereotactic radiosurgery or conventional external beam irradiation, should be strongly considered in selected cases. Limited data exist regarding the role of hormonal treatment or chemotherapy as adjunct therapy. A target therapy modulating the altered molecular balance may be the key to revolutionize the prognosis of these patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurochirurgie - Volume 62, Issue 4, August 2016, Pages 213-222
نویسندگان
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