Developing a physiological model for type II diabetes mellitus

High blood glucose levels in type II diabetic patients often result from the malfunction of different organs such as the pancreas, the liver, muscles, and adipose tissues. Accurate diagnosis of abnormalities associated with type II diabetic patients is essential for administering an effective treatment. In this paper, a model for type II diabetes has been developed based on a detailed compartmental physiological model proposed for a healthy human body. Using available clinical data from type II diabetic patients, the model parameters have been estimated by means of an optimization method for diabetic patients. The estimated model may be used to understand the behavior of different organs in type II diabetic patients. It has been shown that the proposed model can predict the relative deficiency in the pancreatic insulin production, the impaired hepatic regulatory effect on glucose concentrations, and the low peripheral glucose uptake in type II diabetic patients.

► A detailed compartmental physiological model was developed to represent a patient with type II diabetes mellitus.
► The model parameters were estimated from clinical patient measurements.
► Physiological abnormalities associated with type II diabetes mellitus were simulated.
► The simulated results were found to be clinically consistent with physiological responses of type II diabetic patients.