کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3841066 | 1247956 | 2009 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Relaxin and its role in the development and treatment of fibrosis Relaxin and its role in the development and treatment of fibrosis](/preview/png/3841066.png)
Relaxin, which is a peptide hormone of the insulin superfamily, is involved in the promotion of extracellular matrix remodeling. This property is responsible for many well-known reproductive functions of relaxin. Recent important findings, including the identification of the relaxin receptor and the development of the relaxin-null mouse, have identified new targets and mechanisms for relaxin's actions, which resulted in unprecedented advances in the field. Relaxin has emerged as a natural suppressor of age-related fibrosis in many tissues, which include the skin, lung, kidney, and heart. Furthermore, relaxin has shown efficacy in the prevention and treatment of a variety of models of experimentally induced fibrosis. The intention of this review is to present a summary of recent advances in relaxin research, with a focus on areas of potential translational research on fibrosis in nonreproductive organs.
Journal: Translational Research - Volume 154, Issue 1, July 2009, Pages 1–6