کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3841348 1247974 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Involvement of microRNAs in lung cancer biology and therapy
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Involvement of microRNAs in lung cancer biology and therapy
چکیده انگلیسی

MicroRNAs (miRNAs) are a class of small RNAs that regulate gene expression. Expression profiles of specific miRNAs have improved cancer diagnosis and classification as well as provided prognostic information in many human cancers, including lung cancer. Tumor-suppressive and oncogenic miRNAs were uncovered in lung carcinogenesis. The biological functions of these miRNAs in lung cancer were validated recently in well-characterized cellular, murine transgenic as well as transplantable lung cancer models, and in human paired normal-malignant lung tissue banks and tissue arrays. Tumor-suppressive and oncogenic miRNAs that were identified in lung cancer will be reviewed here. Emphasis is placed on highlighting those functionally validated miRNAs that are not only biomarkers of lung carcinogenesis but also candidate pharmacologic targets. How these miRNA findings advance an understanding of lung cancer biology and how they could improve lung cancer therapy are discussed in this article.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Translational Research - Volume 157, Issue 4, April 2011, Pages 200–208
نویسندگان
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