کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3841912 1248010 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sex differences in the effective warfarin dosage in Han and aboriginal Taiwanese patients with the VKORC1-1639AA genotype
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Sex differences in the effective warfarin dosage in Han and aboriginal Taiwanese patients with the VKORC1-1639AA genotype
چکیده انگلیسی

ObjectiveThis study aims to investigate whether single-nucleotide polymorphisms (SNPs) CYP2C9 and VKORC1 can be used to adjust effective warfarin treatment for aboriginal Taiwanese population.Materials and MethodsThis study investigates the association of SNPs CYP2C9 and VKORC1 and clinical factors [sex, age, and body mass index (BMI)] with variable responses to warfarin treatment in 42 aboriginal and 63 Han Taiwanese people.ResultsThe incidence of the VKORC1-1639AA genotype and the effective warfarin dosage were similar in the populations studied. However, the required dosage of warfarin for women with VKORC1-1639AA polymorphism was significantly lower than for their male counterparts.ConclusionThis result provides guidance for prescribing an effective warfarin dosage for aboriginal and Han Taiwanese patients with genetic polymorphisms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tzu Chi Medical Journal - Volume 25, Issue 4, December 2013, Pages 213–217
نویسندگان
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