کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3847481 1598257 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of CKD and Dialysis Modality on Exposure to Drugs Cleared by Nonrenal Mechanisms
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
پیش نمایش صفحه اول مقاله
Effect of CKD and Dialysis Modality on Exposure to Drugs Cleared by Nonrenal Mechanisms
چکیده انگلیسی
Our data suggest that selection of dialysis modality is a major determinant of exposure to the CYP3A4 probe midazolam. Exposure to the intestinal and hepatic transporter probe fexofenadine is altered in patients with NDD-CKD and PD and HD patients. Thus, drug development and licensing of nonrenally cleared drugs should include evaluation in these 3 patient groups, with these results included in approved product information labeling. This reinforces the critical need for more in vivo studies of humans that evaluate the exposure to drugs cleared by these pathways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Kidney Diseases - Volume 65, Issue 4, April 2015, Pages 574-582
نویسندگان
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