Keywords: Triazoles; Antifungal activity; Drug-drug interactions; Tetrazole; CYP3A4;
مقالات ISI (ترجمه نشده)
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Keywords: ABCB1; gene coding the efflux transporter P glycoprotein; AUC; area under the concentration time curve; BPAR; biopsy proven acute rejection; C0; residual whole blood tacrolimus concentration; C24h; whole blood tacrolimus concentration at the end of the 24
Keywords: Therapeutic drug monitoring; Venlafaxine; Quetiapine; Drug-drug interaction; CYP3A4;
Keywords: Herbal medicine; Phytochemical; Human induced pluripotent stem cell; Primary human hepatocyte; CYP3A4;
Keywords: AUD; Alcohol use disorder; FDA; Food and Drug Administration; MOR; Mu opioid receptor; DOR; Delta opioid receptor; KOR; Kappa opioid receptor; NMDA; N-methyl-d-aspartate; GABA; Gaba amino butyric acid; DSM-IV; Diagnostic and statistical measurement IV; PA
Keywords: 5-FU; 5-fluorouracil; CEA; carcinoembryonic antigen; CYP3A4; cytochrome 3A4; DPD; dihydropyrimidine dehydrogenase; ECOG; Eastern Cooperative Oncology Group; EGFR; epidermal growth factor receptor; EMA; European Medicines Agency; FDA; Food and Drug Adminis
Keywords: ADME-Tox; absorption, distribution, metabolism, excretion, and toxicity; AUC; area under the curve; BnSH; benzyl mercaptan; Xantphos; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; CYP2C19; hepatic cytochrome P450 2C19; CYP3A4; hepatic cytochrome P450 3
Keywords: 20-GPPD; 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol; CaM; calmodulin; CaMKII; calmodulin-dependent protein kinase II; CBD; cannabidiol; CBG; cannabigerol; CPZ; capsazepine; CRAC; Ca2+ release-activated Ca2+ channel; CTL; cytotoxic T cells; CYP3A4; cyt
Keywords: ADME-Tox; absorption, distribution, metabolism, excretion, and toxicity; CYP2C19; hepatic cytochrome P450 2C19; CYP3A4; hepatic cytochrome P450 3A4; DSC; differential scanning calorimetry; DIBAL-H; diisobutylaluminium hydride; DME; 1,2-dimethoxyethane; DM
Keywords: Phloroglucinol; Diabetes-Induced Erectile Dysfunction; Sildenafil; CYP3A4; AGEs; Antioxidant
Keywords: BID; twice daily; CBC; complete blood cell count; CDC; Centers for Disease Control and Prevention; CNS; central nervous system; CYP3A4; cytochrome P450 3A4; DOT; directly observed therapy; DST; drug susceptibility testing; ECG; electrocardiogram; HIV; hum
Keywords: CYP3A4; itraconazole; olaparib; pharmacokinetic; rifampin;
Keywords: CYP2C19; cytochrome P450 C19; CYP2C9; cytochrome P450 C9; CYP3A4; cytochrome P450 3A4; HERG; human ether-Ã -go-go-related gene; HPLC; high-pressure liquid chromatography; IKr; rapid component of delayed rectifier potassium current; IKur; ultrarapid acti
Keywords: Pioglitazone; Drug–Drug interaction; Carbamazepine; Pharmacokinetic; CYP3A4
Keywords: BC; Breast cancer; CIPN; Chemotherapy-induced peripheral neuropathy; CYP2D6; Cytochrome P450 2D6; CYP3A4; Cytochrome P450 3A4; DN4; Neuropathic pain in 4 questions; DSST; Digit Symbol Substitution Test; EORTC QLQ-C30; European Organisation for Research an
Keywords: Toremifene; Tamoxifen; Metabolite kinetics; Bioactivation; CYP2D6; CYP3A4; CYP2C9; Pharmacogenomics; PolymorphismsTOR, toremifene; TAM, tamoxifen; SERM, selective estrogen receptor modulator; SSRI, selective serotonin reuptake inhibitor; 4OH, 4-hydroxy; N
Keywords: AED; antiepileptic drug; CBZ; carbamazepine; TDM; therapeutic drug monitoring; CYP3A4; cytochrome P 450 3A4; CBZE; carbamazepine-10,11-epoxide; PK; pharmacokinetics; DBS; dried blood spot; LC-MS/MS; liquid chromatography-tandem mass spectrometry; UV;
Keywords: ABCB1; adenosine triphosphate-binding cassette transporter 1; ASC; apoptosis-associated Speck-like protein containing Caspase recruitment domain; ATP; adenosine triphosphate; Bcl-2; B-cell lymphoma 2; BD; Behcetʼs disease; Ca2+; calcium; Caspase; cystein
Keywords: CYP3A4; drug interaction ketoconazole; lobeglitazone; pharmacokinetics
Keywords: P-gp; P-glycoproteins; BEs; bioactive excipients; AP; apical; BL; basolateral; Papp; apparent permeability; CYP3A4; cytochrome P450 3A; HCC; hepatocellular carcinoma; BBB; blood-brain barrier; ER; Estrogen receptor; Cell line; Nanomedicine; Permeability
Keywords: anesthesia – genetics; pharmacogenetics; drug–drug interactions; drug–gene interactions; CYP2D6; CYP3A4; CYP2B6; opioid metabolism; OPRM1; OPRK1; UGT2B7; COMT; GABA; ABCB1; MC1R
Keywords: CAR; constitutive androstane receptor; CYP2B6; cytochrome P450 2B6; CYP3A4; cytochrome P450 3A4; DMSO; dimethyl sulfoxide; GR; glucocorticoid receptor; HBSS; Hanks' balanced salt solution; hCAR; human constitutive androstane receptor; hGR; human glucoco
Keywords: Cholesterol; Oxysterol; CYP46A1; CYP27A1; CYP3A4; CYP39A1; CYP7B1; CH25H; Cholesterol 7α-hydroxylase; Sterol 27-hydroxylase; Cholesterol 24-hydroxylase; Cholesterol 25-hydroxylase; Oxysterol 7α-hydroxylase; 24-hydroxycholesterol 7α-hydroxylase; Epigene
Keywords: CYP; cytochrome P450; Hepes; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; DEM; diethyl maleate; GSH; reduced glutathione; ROS; reactive oxygen species; Liver injury; Idiosyncrasy; Clopidogrel activation; CYP3A4; Mitochondria; Glutathione; Apoptosis
FOXP3 rs3761549 polymorphism predicts long-term renal allograft function in patients receiving cyclosporine-based immunosuppressive regimen
Keywords: ABCB1; ATP binding cassette subfamily B member 1; CsA; cyclosporine A; CYP3A4; cytochrome P450 3A4; CYP3A5; cytochrome P450 3A5; eGFR; estimated glomerular filtration rate; Foxp3; forkhead box p3; MMF; mycophenolate mofetil; MPA; mycophenolic acid; MPS; c
Interactions of casticin, ipriflavone, and resveratrol with serum albumin and their inhibitory effects on CYP2C9 and CYP3A4 enzymes
Keywords: Casticin; Ipriflavone; Resveratrol; serum albumin; CYP2C9; CYP3A4;
Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research
Keywords: Human induced pluripotent stem cells; CYP3A4; Genome editing; Drug screening; Hepatocytes;
Differential effects of hepatic cirrhosis on the intrinsic clearances of sorafenib and imatinib by CYPs in human liver
Keywords: Sorafenib (PubChem CID: 216239); imatinib (PubChem CID: 5291); midazolam (PubChem CID: 4192); paclitaxel (PubChem CID: 36314); tolbutamide (PubChem CID: 5505); dextromethorphan (PubChem CID: 5360696); Sorafenib biotransformation; Imatinib biotransformatio
An Update on the “Novel” and Direct Oral Anticoagulants, and Long-Term Anticoagulant Therapy
Keywords: Venous thromboembolism; Direct oral anticoagulant (DOAC); P-glycoprotein transport; CYP3A4; Idarucizumab; Thrombin time; Anti-Xa level; Andexanet-alfa;
AMC-Bio-Artificial Liver culturing enhances mitochondrial biogenesis in human liver cell lines: The role of oxygen, medium perfusion and 3D configuration
Keywords: Mitochondrial biogenesis; Bio-artificial liver; HepaRG; C3A; Hepatocyte; ABCA12; ATP binding cassette subfamily A member 12; ACO2; aconitase 2; AMC; Amsterdam Medical Center; BAL; bio-artificial liver; BALIAD; bio-artificial liver-in-a-dish; CEBPa; CCAAT/
Effects of UGT2B7, SCN1A and CYP3A4 on the therapeutic response of sodium valproate treatment in children with generalized seizures
Keywords: VPA; sodium valproate; FABP2; fatty acid binding protein 2; ABCB1; ATP binding cassette subfamily B member 1; ABCC2; ATP binding cassette subfamily C member 2; GABA; gamma-aminobutyric acid; ABAT; 4-aminobutyrate aminotransferase; GABR; GABA receptor; SCN
Steroid bioconjugation to a CYP3A4 allosteric site and its effect on substrate binding and coupling efficiency
Keywords: Cytochrome P450 3A4; Allostery; Progesterone; Testosterone; Coupling; Heme spin-state; BFC; 7-benzyloxy-4-trifluoromethylcoumarin; CPR; cytochrome P450 reductase; CYP3A4; human cytochrome P450 3A4; DTT; 1,4-dithiothreitol; HFC; 7-hydroxy-4-trifluoromethyl
Influence of Renal Function on the Pharmacokinetics, Pharmacodynamics, Efficacy, and Safety of Non-Vitamin K Antagonist Oral Anticoagulants
Keywords: AF; atrial fibrillation; BID; twice daily; CKD; chronic kidney disease; CL/F; apparent total clearance after oral administration; CrCL; creatinine clearance; CYP3A4; cytochrome P450 3A4; DVT; deep vein thrombosis; eGFR; estimated glomerular filtration rat
In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants
Keywords: AUC; area under the plasma concentration vs. time curve; CL; total body clearance; P450; general term for cytochrome P450 (EC 1.14.14.1); V; volume of distribution; Marmoset; CYP3A4; CYP2C19; Polymorphism; PBPK;
Sagittaria sagittifolia polysaccharide protects against isoniazid- and rifampicin-induced hepatic injury via activation of nuclear factor E2-related factor 2 signaling in mice
Keywords: CYP2E1; CYP3A4; Hepatoprotective mechanism; NRF2 signaling;
Simultaneous determination of intestinal permeability and potential drug interactions of complex mixtures using Caco-2â¯cells and high-resolution mass spectrometry: Studies with Rauwolfia serpentina extract
Keywords: Caco-2â¯cells; CYP3A4; Glucuronosyltransferase; Methods; Rauwolfia serpentina;
Piperine potentiates curcumin-mediated repression of mTORC1 signaling in human intestinal epithelial cells: implications for the inhibition of protein synthesis and TNFα signaling
Keywords: Akt; AKT serine/threonine kinase 1; BCA; bicinchoninic acid; BRAF; B-Raf proto-oncogene, serine/threonine kinas; COX-2; cyclooxygenase-2; CUR; curcumin; CYP3A4; cytochrome P450 3A4; DMSO; dimethyl sulfoxide; DTT; dithiothreitol; eEF2; eukaryotic translati
Association between MDR1/CYP3A4/OPRM1 gene polymorphisms and the post-caesarean fentanyl analgesic effect on Chinese women
Keywords: MDR1; Multidrug Resistance 1; CYP3A4; Cytochrome P450 3A4; OPRM1; μ-opioid receptor; SNPs; Single-nucleotide polymorphisms; Cor; Cortisol; Ang-1; Angiotensin; MAP; Mean arterial pressure; HR; Heart rate; Single-nucleotide polymorphism; Fentanyl; Pharmaco
Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects
Keywords: CYPs; cytochrome P450s; HDIs; herb-drug interactions; HLMs; human liver microsomes; NADPï¼; β-nicotinamide adenine dinucleotide phosphate; QSAR; quantitative structure activity relationship; CoMFA; comparative molecular field analysis; LC-MS; liquid c
Structural properties for selective and efficient l-type amino acid transporter 1 (LAT1) mediated cellular uptake
Keywords: ARPE-19; a human retinal pigment epithelial cell line; ATCC; American Type Culture Collection; ASCT2; alanine-serine-cysteine transporter 2; BBB; Blood Brain Barrier; BCH; 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid; CNS; Central Nervous System; CYP3
Novel hydrazide-hydrazone and amide substituted coumarin derivatives: Synthesis, cytotoxicity screening, microarray, radiolabeling and in vivo pharmacokinetic studies
Keywords: Coumarin hydrazide-hydrazone; Apoptosis; Caspases 3/7; GST; CYP3A4; Microarray; Radiolabeling;
Decreased tacrolimus plasma concentrations during HCV therapy: a drug-drug interaction or is there an alternative explanation?
Keywords: Hepatitis C virus; HCV; Tacrolimus; Direct-acting antiviral; CYP3A4;
Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis
Keywords: Gomisin C; Gomisin G; CYP3A4; CYP3A5; Inhibition; Herb-drug interactions;
Discovery of renin inhibitors containing a simple aspartate binding moiety that imparts reduced P450 inhibition
Keywords: Renin inhibitors; Cyp3A4; Biphenyl; Hypertension; X-ray crystallography;
Short communicationDifferential protein expression and localization of CYP450 enzymes in three species of earthworm; is this a reflection of environmental adaptation?
Keywords: Earthworm; CYP450; CYP1A2; CYP2E1; CYP3A4; Western blot;
Alisol B 23-acetate from the rhizomes of Alisma orientale is a natural agonist of the human pregnane X receptor
Keywords: Alisol B 23-acetate; Alisma orientale; Pregnane X receptor; Alisma rhizome; Nuclear receptor; CYP3A4; cytochrome P450 3A4; DMEs; drug metabolizing enzymes; HPH; human primary hepatocyte; ABA; alisol B 23-acetate; PXR; pregnane X receptor; SRC-1; steroid r
Cytochrome P450 binding studies of novel tacrine derivatives: Predicting the risk of hepatotoxicity
Keywords: Cholinesterase inhibitors; Tacrine; Hepatotoxicity; Cytochrome P450; CYP1A2; CYP3A4; Molecular docking; 3,4-Dimethoxybenzylamino;
Development of Caco-2 cells co-expressing CYP3A4 and NADPH-cytochrome P450 reductase using a human artificial chromosome for the prediction of intestinal extraction ratio of CYP3A4 substrates
Keywords: CYP3A4; NADPH-cytochrome P450 reductase; Caco-2Â cells; Human artificial chromosome vector; Intestinal metabolism; ABT; 1-aminobenzotriazole; CLint; intrinsic clearance; CPR; NADPH-cytochrome P450 reductase; Ct; threshold cycle; CYP; cytochrome P450; Eg;
Metabolic-induced cytotoxicity of diosbulbin B in CYP3A4-expressing cells
Keywords: AP; Acetaminophen; CCK; 2H-Tetrazolium,5-(2,4-disulfophenyl)-3-(2-methoxy-4-nitrophenyl)-2-(4-nitrophenyl)-,innersalt,sodium salt; CYP450; Cytochrome P450; DB; Diosbulbin B; DMEM; Dulbecco's Modified Eagle Medium; DMF; N,N-Dimethylformamide; DMSO; D
In silico and in vitro inhibition of cytochrome P450 3A by synthetic stilbenoids
Keywords: CYP; cytochrome P450; P450s; cytochrome P450 enzymes; RLM; rat liver microsomes; CYP3A4; Resveratrol; Nitrostilbene; Di-methoxy-nitrostilbene; Microsomes; Docking;