Therapeutic drug monitoring of carbamazepine and its metabolite in children from dried blood spots using liquid chromatography and tandem mass spectrometry

- A novel approach for analysis of CBZ and its metabolite in DBS employing LC-MS/MS.
- It offers simultaneous determination of CBZ and its metabolite.
- The method was validated and found to be accurate, precise and robust.
- This method offers a surrogate to plasma sampling for TDM in paediatric patients.