کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3848457 | 1598282 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bilirubin-Associated Acute Tubular Necrosis in a Kidney Transplant Recipient
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Bilirubin-Associated Acute Tubular Necrosis in a Kidney Transplant Recipient Bilirubin-Associated Acute Tubular Necrosis in a Kidney Transplant Recipient](/preview/png/3848457.png)
چکیده انگلیسی
Unlike hemoglobin or myoglobin, bilirubin, a breakdown product of the catabolism of heme molecules, usually is not seen as a nephrotoxic protein. We report the case of an adult kidney recipient who developed jaundice 4 years after transplantation because of a malignant cholangiocarcinoma. He progressively lost transplant function, accompanied by a continuous increase in bilirubinemia. Kidney biopsy showed bile granules in the cytoplasm of tubular epithelial cells and bile thrombi in dilated tubules, but no interstitial inflammation. The tumor was unresectable and the patient died 2 months later. Because the patient had no jaundice-associated confounding factor that could explain his kidney failure, such as sepsis, heart failure, or liver failure with hepatorenal syndrome, this exceptional case suggests that bilirubin per se should be seen as a potential cause of acute tubular necrosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Kidney Diseases - Volume 61, Issue 5, May 2013, Pages 782-785
Journal: American Journal of Kidney Diseases - Volume 61, Issue 5, May 2013, Pages 782-785
نویسندگان
Cédric MD, Maren BM, Isabelle MD, PhD, Lara MD, PhD, Patrice MD, Eric MD, PhD, Alexandre MD, PhD,