کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3852734 | 1598388 | 2006 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Carotid Plaques and Their Predictive Value for Cardiovascular Disease and All-Cause Mortality in Hemodialysis Patients Considering Renal Transplantation: A Decade Follow-Up
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
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چکیده انگلیسی
Background: Carotid plaque formation is very common in dialysis patients. The prognostic value of plaques, both calcified and noncalcified, rarely was investigated prospectively in these patients. By using a carotid plaque score, this study aims to determine the risk for combined cardiovascular disease (CVD) events and all-cause mortality in 165 hemodialysis patients in a long-term follow-up considering phases of renal transplantation. Methods: Baseline carotid ultrasonography was performed in 165 hemodialysis patients to screen for carotid plaques. Patients subsequently were followed up for a period up to 13 years (average, 86 months). Because of biases associated with renal transplantation, 3 methods of multivariate analysis were compared by using Cox proportional hazards regression models. Results: Plaques were present in 107 of 165 patients (65%). During the observation period, 50 patients (30%) experienced a combined CVD event, 95 patients (58%) died, and 79 patients (48%) underwent at least 1 renal transplantation. Mean plaque score differed significantly between patients who reached an end point and those who did not (CVD events, 3.1 ± 2.7 versus 2.0 ± 2.4; P = 0.01; all-cause mortality, 3.5 ± 2.6 versus 0.9 ± 1.3; P < 0.001). Plaque score entered all 3 tested Cox regression models for CVD events and all-cause mortality. The lowest statistical power was associated with censoring at the time of renal transplantation. Not considering transplantation at all neglected a major change in risk. Conclusion: We identified carotid plaque score and treatment modality as highly significant predictors for CVD events and all-cause mortality.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Kidney Diseases - Volume 47, Issue 5, May 2006, Pages 888-897
Journal: American Journal of Kidney Diseases - Volume 47, Issue 5, May 2006, Pages 888-897
نویسندگان
Johannes P. MD, Claudia MSc, Ulrich MD, Paul MD, Hermann MD, Wolfgang MD, Karl MD, Ernst MD, Hans PhD, Florian MD,