کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3890713 1249998 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cell-based therapies in kidney disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
پیش نمایش صفحه اول مقاله
Cell-based therapies in kidney disease
چکیده انگلیسی

Cell-based therapy is an emerging field but one that has shown early promise for the treatment of human kidney diseases. The most widely used cell is the mesenchymal stem cell (MSC) given its ability to be harvested from bone marrow, expanded in culture, and used in allogeneic protocols. The beneficial effects of MSCs occur through differentiation-independent pathways that include increased cell survival and proliferation, decreased inflammation, and suppression of immune function. Acute kidney injury and kidney transplantation are the two conditions most frequently treated with MSC infusion. Although initial studies are promising, the long-term efficacy and safety of MSC infusion awaits further study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Kidney International Supplements - Volume 3, Issue 4, 1 December 2013, Pages 364–367
نویسندگان
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