کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3896941 1250236 2008 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aquaporin 2 Mutations in Nephrogenic Diabetes Insipidus
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
پیش نمایش صفحه اول مقاله
Aquaporin 2 Mutations in Nephrogenic Diabetes Insipidus
چکیده انگلیسی
Water reabsorption in the renal collecting duct is regulated by the antidiuretic hormone vasopressin (AVP). When the vasopressin V2 receptor, present on the basolateral site of the renal principal cell, becomes activated by AVP, aquaporin-2 (AQP2) water channels will be inserted in the apical membrane, and in this fashion, water can be reabsorbed from the pro-urine into the interstitium. The essential role of the vasopressin V2 receptor and AQP2 in the maintenance of body water homeostasis became clear when it was shown that mutations in their genes cause nephrogenic diabetes insipidus, a disorder in which the kidney is unable to concentrate urine in response to AVP. This review describes the current knowledge on AQP2 mutations in nephrogenic diabetes insipidus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Nephrology - Volume 28, Issue 3, May 2008, Pages 252-265
نویسندگان
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