کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3935402 | 1253412 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Substandard application of preimplantation genetic screening may interfere with its clinical success
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
زنان، زایمان و بهداشت زنان
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چکیده انگلیسی
The intent of this study was to evaluate a recent randomized clinical trial evaluating the effect of preimplantation genetic screening (PGS) that reports a negative effect on pregnancy outcome. This article reviews appropriate PGS techniques and how they differ from the trial in question. A closer look at the clinical trial in question reveals significant lack of expertise in biopsy, cell fixation, genetic analysis, and patient selection. At most, this trial demonstrates that in inexperienced hands, PGS can be detrimental. No other conclusions concerning the effect of PGS on pregnancy results can be drawn from the trial.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 88, Issue 4, October 2007, Pages 781–784
Journal: Fertility and Sterility - Volume 88, Issue 4, October 2007, Pages 781–784
نویسندگان
Santiago Munné, Luca Gianaroli, Ilan Tur-Kaspa, Cristina Magli, Mireia Sandalinas, Jamie Grifo, David Cram, Semra Kahraman, Yury Verlinsky, Joe L. Simpson,