کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3938656 1253538 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduced expression of biomarkers associated with the implantation window in women with endometriosis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Reduced expression of biomarkers associated with the implantation window in women with endometriosis
چکیده انگلیسی

ObjectiveTo evaluate the expression of biomarkers of implantation, glycodelin A (GdA), osteopontin (OPN), lysophosphatidic acid receptor 3 (LPA3), and HOXA10, in eutopic endometrium of women with and without endometriosis.DesignProspective observational study.SettingClinical research center.Patient(s)Twenty-four women with endometriosis and 23 healthy volunteers of similar age.Intervention(s)Secretory phase endometrial biopsy.Main Outcome Measure(s)Expression of immunohistochemical staining intensity and localization of GdA, OPN, LPA3, and HOXA10 in eutopic endometrium.Result(s)Endometrial GdA expression was significantly reduced in patients after cycle day 22. The endometrium from women with endometriosis also showed decreased expression of OPN in the late secretory phase and LPA3 and HOXA10 expression in the midsecretory and late secretory phases.Conclusion(s)The decreased expression of these four biomarkers of implantation may indicate impaired endometrial receptivity in patients with endometriosis, providing one explanation for the subfertility observed even in women with few pelvic implants. Because many of these markers are P dependent, these findings suggest the possibility of reduced endometrial P action in this population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 91, Issue 5, May 2009, Pages 1686–1691
نویسندگان
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