کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3941595 1253617 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of hormonal treatment on nerve fibers in endometrium and myometrium in women with endometriosis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Effects of hormonal treatment on nerve fibers in endometrium and myometrium in women with endometriosis
چکیده انگلیسی

ObjectiveTo investigate how hormonal treatment can change nerve fiber density and to identify types of nerve fibers in endometrium and myometrium in women with endometriosis.DesignLaboratory study using human tissue.SettingUniversity-based laboratory.Patient(s)Hormonally treated and untreated women with endometriosis undergoing hysterectomy or curettage.Intervention(s)Endometrial and myometrial tissues were prepared from women with hormonally treated endometriosis and women with untreated endometriosis.Main Outcome Measure(s)Types and density of nerve fibers in endometrium and myometrium in women with hormonally treated and untreated endometriosis were determined immunohistochemically.Result(s)The nerve fiber density (mean density ± SD per square millimeter) in the functional and the basal layers of endometrium (0.2 ± 0.7/mm2 and 0.9 ± 1.3/mm2, respectively) and myometrium (1.5 ± 0.8/mm2) from women with hormonally treated endometriosis was much lower than that of endometrium (functional layer: 11 ± 5/mm2, basal layer: 18 ± 8/mm2, respectively) and myometrium (3 ± 1/mm2) from women with untreated endometriosis. Nerve growth factor and nerve growth factor receptor p75 expression was also significantly reduced in women with hormonally treated endometriosis compared with women with untreated endometriosis.Conclusion(s)Hormonal treatment significantly reduced nerve fiber density in endometrium and myometrium in women with endometriosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 90, Issue 5, November 2008, Pages 1589–1598
نویسندگان
, , , ,