کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3942363 1253684 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Local application of danazol-loaded hyaluronic acid hydrogel to endometriosis in a rat model
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Local application of danazol-loaded hyaluronic acid hydrogel to endometriosis in a rat model
چکیده انگلیسی

ObjectiveTo evaluate the efficacy of a drug delivery system composed of danazol-loaded hyaluronic acid for local application to endometriosis.DesignProspective, randomized study.SettingAcademic research unit of the department of obstetrics and gynecology in a university hospital.Patient(s)Adult female Sprague-Dawley rats.Intervention(s)Danazol-loaded hyaluronic acid hydrogel (DZ-HA gel) was injected into the rat endometriosis model.Main Outcome Measure(s)Size and histological changes in experimental endometriosis, the concentration of danazol in the cyst wall and plasma, and estrous cycles were examined.Result(s)Histologically, DZ-HA gel-treated cysts displayed marked atrophy of the endometrial epithelium. Increased numbers of apoptotic cells and decreased numbers of proliferative cells were noted with 10 mg/mL DZ-HA gel. Size of treated cysts decreased to approximately 60% at 9 weeks after injection. The estrous cycles were not disturbed during DZ-HA gel treatment.Conclusion(s)Local injection of DZ-HA gel achieved endometrial atrophy of an experimental model of endometriosis without disturbing the sexual cycle. These results suggest that local application of DZ using this drug delivery system may prove useful for treating endometriosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 85, Supplement 1, April 2006, Pages 1157–1167
نویسندگان
, , , , , ,