کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3942800 | 1254042 | 2014 | 6 صفحه PDF | دانلود رایگان |
• Without compromising the oncologic outcomes, 30% endometrial cancer patients do not need lymphadenectomy (the “not at risk subgroup”).
• Our reference data inform lymphadenectomy and adjuvant therapy decisions in the “at risk subgroup” (remaining 70%) of endometrial cancer.
• Paraaortic lymphadenectomy, when undertaken, ought to include management of the high paraaortic area (above the inferior mesenteric artery).
ObjectiveTo prospectively define the prevalence of lymph node metastasis (LNM) in at risk endometrial cancer (EC).MethodsFrom 2004 to 2008, frozen section based Mayo Criteria prospectively identified patients “not at-risk” of LNM (30% EC population; grade I/II, < 50% myometrial invasion and tumor diameter ≤ 2 cm) where lymphadenectomy was not recommended. The remaining 70% EC cohort was considered “at-risk” of LNM; where a systematic pelvic and infrarenal paraaortic lymphadenectomy was recommended. Patients were prospectively followed. The area between renal vein and inferior mesenteric artery (IMA) was labeled as high paraaortic area. For calculating the prevalence of LNM in high paraaortic area, the denominator was the population with known anatomic location of nodal tissue in relation to the IMA.ResultsOf the 742 patients, 514 were at risk; of which 89% underwent recommended lymphadenectomy. A mean (± standard deviation) of 36 (± 14) pelvic and 18 (± 9) paraaortic nodes were harvested. The prevalence of pelvic and paraaortic LNM was 17% and 12%, respectively. In presence of pelvic LNM, 51% had paraaortic LNM. In absence of pelvic LNM, 3% had paraaortic LNM; of which 67% was located exclusively in high paraaortic area. Among patients with paraaortic LNM, 88% had high paraaortic LNM; and 35% had only high paraaortic LNM. The cases of paraaortic LNM with negative pelvic nodes seemed to cluster in moderate to high grade endometrioid EC with ≥ 50% myometrial invasion.ConclusionWe present reference data for the prevalence of LNM in at-risk EC patients to guide lymphadenectomy decisions for clinical and research purposes.
Journal: Gynecologic Oncology - Volume 132, Issue 1, January 2014, Pages 38–43