کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3950136 | 1600409 | 2008 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Prenatal diagnosis of chromosomal abnormalities in a resource-poor setting Prenatal diagnosis of chromosomal abnormalities in a resource-poor setting](/preview/png/3950136.png)
ObjectiveTo compare the efficacy and efficiency of systematic, ultrasound-based risk adjustment using a published algorithm with that of a maternal age cutoff of 37 years for the prenatal detection of chromosomal abnormalities (especially autosomal trisomies).MethodsThese approaches were compared in a retrospective study of 136 chromosomal abnormalities confirmed by karyotyping prenatally (n = 46) or postnatally (n = 90). There were 114 autosomal trisomies.ResultsMaternal age was known for 103 fetuses with confirmed abnormalities. The ultrasound-based risk adjustment approach was more sensitive for autosomal trisomy (93.9% vs 44.1%), and karyotyping for younger women with abnormalities on ultrasound was more effective than routine karyotyping in older women (1 trisomy detected in 13.5 vs 42.8 samples, P < 0.001). A lack of screening was the main reason for the postnatal diagnosis.ConclusionUltrasound-based risk adjustment was the more effective approach.
Journal: International Journal of Gynecology & Obstetrics - Volume 103, Issue 1, October 2008, Pages 16–21