کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3966223 | 1256145 | 2012 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Maternal XX/X chromosome mosaicism in donor oocyte in vitro fertilization (IVF) Maternal XX/X chromosome mosaicism in donor oocyte in vitro fertilization (IVF)](/preview/png/3966223.png)
ObjectiveTo evaluate if the degree of maternal X chromosome mosaicism is correlated to the pregnancy loss rate in donor oocyte IVF in women with a Turner syndrome mosaic (TS-Mosaic) diagnosis.DesignProspective trial.Patients and methodsWomen with X chromosome Turner syndrome mosaicism and infertility were enrolled in a clinical trial. The rate of mosaicism was determined through florescence in situ hybridization (FISH) of 500 maternal lymphocytes. Following a detailed medical, including cardiac, evaluation, donor oocyte in vitro fertilization (IFV) was performed and pregnancy and pregnancy loss rates were observed.ResultsThe rates of maternal X chromosome mosaicism noted in the cycles from women with miscarriages (3%, 4%, 4%, and 6%) were not statistically different from cycles in TS-Mosaic women with normal deliveries (3% and 11%). These data suggest that the rate of maternal X chromosome mosaicism does not affect pregnancy loss rates in TS-Mosaic women undergoing donor oocyte IVF.
Journal: Middle East Fertility Society Journal - Volume 17, Issue 2, June 2012, Pages 129–133