Effect of SPP 635, a renin inhibitor, on intraocular pressure in glaucomatous monkey eyes

► SPP 635, a renin inhibitor, was investigated in this study. ► Renin inhibitors are a different class of compounds from those in current use. ► SPP 635 reduces IOP in glaucomatous monkey eyes in dose-dependent manner. ► SPP 635 may have potential for the treatment of glaucoma.