Anatomical evidence of photoreceptor degeneration induced by iodoacetic acid in the porcine eye

► Systemic administration of IAA induces preferential damage to photoreceptors in the pig. ► IAA induces rapid robust degeneration of photoreceptors. ► Rods appear to be more sensitive to IAA than cones. ► IAA induces subtle changes to specific cell populations in the inner retina. ► IAA induces photoreceptor degeneration while relatively sparing the inner retina.