کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4011907 1261170 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hypothermia prevents the development of ischemic proliferative retinopathy induced by severe perinatal asphyxia
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی و میکروب شناسی (عمومی)
پیش نمایش صفحه اول مقاله
Hypothermia prevents the development of ischemic proliferative retinopathy induced by severe perinatal asphyxia
چکیده انگلیسی

Obstetric complications, such as perinatal asphyxia, may cause retinal injuries as retinopathy of prematurity (ROP), a type of ischemic proliferative retinopathy. Up to date there are no appropriate experimental models for studying the long-term sequels of this disease. In the present work, we present an experimental model of perinatal asphyxia which shows structural and ultrastructural retinal alterations at the most inner layers of the retina, such as neurodegeneration, development of neoformed vessels and glial reaction, which are compatible with the histopathological description of ROP. Besides, the application of hypothermia during perinatal asphyxia showed effective results preventing cellular and morphological alterations. This study may contribute to the development of therapies in order to either ameliorate or prevent retinal damage. In this manner, hypothermia may improve life quality and decrease medical, family and social costs of these avoidable causes of blindness.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Eye Research - Volume 90, Issue 1, January 2010, Pages 113–120
نویسندگان
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