کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4012217 | 1261184 | 2008 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antioxidant effects of vitamins C and E, multivitamin-mineral complex and flavonoids in a model of retinal oxidative stress: The ApoE-deficient mouse
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی و میکروب شناسی (عمومی)
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چکیده انگلیسی
The aim of the current study was to investigate the biochemical changes in the plasma and retina of apolipoprotein E deficient (apoEâ/â) mice supplemented with various antioxidants. Ten wild type (WT-Con, C57BL/6) and 10 apoEâ/â (AE-Con) mice received drinking water. Another 40 apoEâ/â animals were divided into four groups of 10 mice each and received either chromocarbe diethylamine (AE-CD, 50Â mg/kg), cyaninosides chloride (AE-CC, 50Â mg/kg), multivitamin complex (AE-MC, 50Â mg/kg), or vitamins C and E (AE-CE, 100Â mg/kg and 200Â IU/kg). Cholesterol, triglycerides, and lipid peroxidation (thiobarbituric acid reactive substances [TBARS]) were measured in plasma, and TBARS and nitric oxide metabolites (NOx) concentration were determined in retinal homogenates. Transmission electron microscopy was performed to examine the retinal ultrastructure. AE-Con mice had significantly (PÂ <Â 0.05) increased oxidative stress in the plasma and retina with augmented production of retinal NOx compared with WT-Con mice. Retinal TBARS decreased in the AE-MC and AE-CE animals compared with the AE-Con group (PÂ <Â 0.05 and PÂ <Â 0.01, respectively). Only AE-CE treatment significantly (PÂ <Â 0.01) lowered retinal NOx. Morphologic retinal changes in the AE-Con group decreased in the AE-CE and AE-MC groups. There were no significant changes in the biochemical and structural parameters in the AE-CD and AE-CC groups. AE-Con mice had increased systemic and retinal oxidative stress compared with WT-Con animals. Vitamins C and E and the multivitamin-mineral complex reduced oxidative stress and ultrastructural retinal changes in this murine model of hypercholesterolemia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Eye Research - Volume 86, Issue 3, March 2008, Pages 470-479
Journal: Experimental Eye Research - Volume 86, Issue 3, March 2008, Pages 470-479
نویسندگان
Luis M. Sádaba, Patricia Fernández-Robredo, José Antonio RodrÃguez, Alfredo GarcÃa-Layana,