From quantitative protein complex analysis to disease mechanism

Interest in the field of cilia biology and cilia-associated diseases – ciliopathies – has strongly increased over the last few years. Proteomic technologies, especially protein complex analysis by affinity purification-based methods, have been used to decipher various basic but also disease-associated mechanisms. This review focusses on some selected recent studies using affinity purification-based protein complex analysis, thereby exemplifying the great possibilities this technology offers.

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► Protein complex analysis.
► Affinity purification.
► Proteomic approach to study ciliopathies.