کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4070880 1604414 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Developmental Biology and Classification of Congenital Anomalies of the Hand and Upper Extremity
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
پیش نمایش صفحه اول مقاله
Developmental Biology and Classification of Congenital Anomalies of the Hand and Upper Extremity
چکیده انگلیسی

Recent investigations into the mechanism of limb development have clarified the roles of several molecules, their pathways, and interactions. Characterization of the molecular pathways that orchestrate limb development has provided insight into the etiology of many limb malformations. In this review, we describe how the insights from developmental biology are related to clinically relevant anomalies and the current classification schemes used to define, categorize, and communicate patterns of upper limb malformations. We advocate an updated classification scheme for upper limb anomalies that incorporates our current molecular perspective of limb development and the pathogenetic basis for malformations using dysmorphology terminology. We anticipate that this scheme will improve the utility of a classification as a basis for diagnosis, treatment, and research.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Hand Surgery - Volume 35, Issue 12, December 2010, Pages 2066–2076
نویسندگان
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