کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4095168 1268517 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Growth and Differentiation Factor-5: New Frontiers to Bone Repair and Spinal Fusion
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
پیش نمایش صفحه اول مقاله
Growth and Differentiation Factor-5: New Frontiers to Bone Repair and Spinal Fusion
چکیده انگلیسی

Recombinant human growth/differentiation factor-5 is a novel bioactive currently in clinical trials. This growth factor was discovered in 1992 and underwent significant preclinical evaluation, as described herein. It was implanted—lyophilized on a mineralized collagen strip—in spinal and long-bone defects, in animals ranging from rats to nonhuman primates. Bone formation resulting from the use of this growth factor was found in all cases to be at least equivalent to that observed with autograft. In addition, saline solutions of this bioactive successfully restored disc height in rabbit models. This new molecule may therefore open new therapeutic avenues for spine regeneration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Spine Surgery - Volume 18, Issue 1, March 2006, Pages 26–32
نویسندگان
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