کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4109043 1605665 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Telomerase activity detection in cholesteatoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های گوش و جراحی پلاستیک صورت
پیش نمایش صفحه اول مقاله
Telomerase activity detection in cholesteatoma
چکیده انگلیسی

BackgroundIn cholesteatoma, there is lack of control over cell proliferation that is why ectodermal tissue grows to be an epidermoid cyst. So cholesteatoma may be considered as cell growth disorder but still the cause of this uncontrolled proliferation is unknown.ObjectiveThe aim of this study is to detect telomerase activity in cholesteatoma and meatal skin (as a control) and its relation to the clinical findings and severity of the disease.Patients and methodsSamples of cholesteatoma and meatal skin were obtained from 31 patients during ear surgery. Telomerase activity was detected using polymerase chain reaction based on telomeric repeat amplification protocol assay then collected data were statistically analyzed.ResultsTelomerase activity was positive in 17/31 (54.8%) of cholesteatoma samples and was negative in all meatal skin samples. Significant high rates of intraoperative ossicular erosion and preoperative air bone gap more than 40 dB were associated with positive telomerase activity.ConclusionsTelomerase activity may play a role in the hyperproliferative nature and uncontrolled aggressive growth pattern of cholesteatoma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Egyptian Journal of Ear, Nose, Throat and Allied Sciences - Volume 14, Issue 1, March 2013, Pages 7–10
نویسندگان
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