Eotaxin, RANTES and tumor necrosis factor alpha levels in allergic rhinitis

ObjectivesThe objectives of this study were to estimate the levels of eotaxin, RANTES and tumor necrosing factor-∞ in allergic rhinitis and their relation to disease severity.Study designProspective study.SettingMansoura University Hospital.Patients and methodsTwenty nine patients suffering from allergic rhinitis were included in this study (19 patients with allergic rhinitis and 10 patients control group). The patients underwent estimation of eotaxin, RANTES, TNF-∞ in the nasal wash using Elisa technique. The patients were divided according to the disease severity into mild allergic rhinitis, severe allergic rhinitis and control groups.ResultsThe mean values of eotaxin, RANTES, TNF-∞ in severe allergic rhinitis (33.6 ± 11.07 pg/ml, 72.17 ± 87.61 pg/ml, 25.47 ± 4.04 pg/ml) were statistically higher than in mild allergic rhinitis (9.80 ± 6.79 pg/ml, 10.50 ± 6.90 pg/ml, 12.99 ± 3.27 pg/ml) and the mean values of all these parameters were higher in both groups compared to control group (0.6 ± 0.69 pg/ml, 0.65 ± 0.74 pg/ml, 0.63 ± 0.54 pg/ml).ConclusionThis study suggests the role of local chemokines in the pathogenesis of allergic rhinitis as well as their possible relation to the severity of the disease which may direct the attention to therapeutic trials against these locally produced chemokines.