کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4111399 1605980 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
To anticoagulate? Controversy in the management of thrombotic complications of head & neck infections
ترجمه فارسی عنوان
برای ضد انعقاد اختلاف نظر در مدیریت عوارض ترومبوز عفونت سر و گردن
کلمات کلیدی
لایمیر؛ اطفال؛ عفونت؛ ترومبوفلبیت؛ ضد انعقاد؛ فارنژیت
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های گوش و جراحی پلاستیک صورت
چکیده انگلیسی

ObjectiveTo review the thrombotic complications of head and neck infections, including Lemierre's syndrome, and their management.MethodsA retrospective review of pediatric patients presenting to McMaster Children's Hospital from 2009 to 2013 was undertaken. The literature was reviewed for evidence regarding the use of anticoagulation therapy in this population.ResultsEleven cases (6 males, 5 females) were identified. The median age was 10.9 (range 14 months–17 years). The most frequent head and neck infection causing a thrombotic complication was mastoiditis (n = 6). All had thrombi identified on imaging, with the most common location being the sigmoid sinus (n = 6) followed by the internal jugular vein (n = 5). All 11 patients were anti-coagulated with low molecular weight heparin (LMWH) within a median of 2 days of diagnosis (average duration 105.8 days). Ten patients (90.9%) had thrombus improvement or resolution within a median of 3.4 months (range 1.0–13.9). Adverse sequelae from the thrombi were MCA infarct (n = 1), septic pulmonary emboli (n = 4), cranial nerve palsies (n = 3) and Horner's syndrome (n = 2). There were no adverse effects from anti-coagulation therapy. Review of the literature revealed anticoagulant use in 63.7% of pediatric cases reported since 2002.ConclusionAnticoagulation remains controversial in the management of thrombotic complications from head and neck infections. Based on this case series, certain recommendations can be made regarding the benefits of anticoagulation, which appear to outweigh the risks. Further research is required to establish evidence for consensus in the antithrombotic management of thrombotic sequelae of head and neck infections.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pediatric Otorhinolaryngology - Volume 88, September 2016, Pages 129–135
نویسندگان
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